Oropharyngeal cancer incidence and mortality rising in nearly all 50 states, reports new national study

Oropharyngeal cancer incidence among men is continuing to rise rapidly in nearly all 50 states and among women living in states in the Midwest and Southeast regions, according to a new study by investigators at The University of Texas Health Science Center at Houston (UTHealth休斯顿) School of Public Health inJAMA耳鼻喉科和颈部手术.

In addition, the investigators found that the number of people diagnosed with large tumors as well as the death rate has increased in the last decade.

“Our study is the first to assess comprehensively oropharyngeal cancer incidence and mortality trends in all 50 states according to demographics as well as tumor characteristics at diagnosis,” saidAshish A. Deshmukh，该研究的高级作者兼管理，政策与社区卫生系的高级作者兼副教授，以及Uthealth公共卫生学院卫生服务研究中心副主任。beplay苹果手机能用吗

“Rising oropharyngeal cancer among men is a documented public health concern. Unfortunately, women in the Midwest and Southeast are also increasingly suffering from this disease,” Deshmukh said.

口咽癌发生在口腔后面的喉咙中部。在过去的十年中，它超越了宫颈癌，成为人类乳头瘤病毒（HPV）引起的最常见的癌症。每年在美国，在美国男性和女性中诊断出近20,000例口咽癌病例。

“The marked increases in incidence among elderly men and advanced-stage tumors, as well as the concurrent increase in mortality in the last decade, are troubling,” said Haluk Damgacioglu, PhD, the study’s lead author and a postdoctoral fellow at UTHealth School of Public Health.

The investigators used the U.S. Cancer Statistics, National Center for Health Statistics (death certificate data), and the Surveillance, Epidemiology, and End Results Program incidence-based mortality data file to examine oropharyngeal cancer incidence and mortality by demographics, tumor characteristics at diagnosis, and geography in all 50 U.S. states and the District of Columbia.

研究人员beplay苹果手机能用吗发现了2001年至2017年之间的260,182例口咽癌病例和111,291例死亡。他们发现，男性的口咽癌发病率每年增加2.7％，非西班牙裔白人男性，年龄在65岁和老年人中以及生活在65岁的男性中，以及生活在65岁的男性中，以及生活在65岁的男性中，以及生活在65岁的男性中，居住在65岁的男性中。该国中西部和东南地区。研究人员还报告说，居住在中西部和东南地区的妇女中，每年增加了2％的口咽癌发病率。

Among men, oropharyngeal cancer incidence increased in all states with the exception of Alaska and Wyoming. Incidence also did not rise in the District of Columbia. Among the top 15 states with the most noticeable annual increase, eight are located in the Midwest and three in the Southeast. The Midwest states are South Dakota (6%); Kansas (4.7%); Iowa (4%); Ohio (3.7%); Indiana (3.6%); Minnesota (3.5%); Missouri (3.4%); and Nebraska (3.4%). The Southeast states are Kentucky (3.9%), West Virginia (3.8%) and Tennessee (3.8%). For women, a marked rise was also concentrated in these Southeast and Midwest states: Louisiana (3.1%), Kentucky (2.7%), Arkansas (2.6%), Mississippi (2.4%), Maryland (1.2%), and North Carolina (1.3%) in the Southeast; Indiana (2.4%), Ohio (2.2%), Iowa (2.0%), and Missouri (1.3%) in the Midwest.

在2001 - 2017年期间，诊断为大肿瘤的男性口咽癌病例每年增长超过4％。在2006年至2017年之间，男性口咽癌死亡率也增加了2％以上。

“More than 70% of oropharyngeal cancer cases are caused by HPV, and more than 90% of HPV-associated oropharyngeal cancers could be potentially prevented if the current generation of adolescents receives the recommended number of HPV vaccine doses,” Damgacioglu said.

Previous research led by study coauthor and UTHealth Houston assistant professor Kalyani Sonawane, PhD, shows that states in the Midwest and Southeast have some of the lowest HPV vaccination rates in the country, and at least 55% of the parents of unvaccinated adolescents are hesitant to initiate HPV vaccination.

Deshmukh说：“克服疫苗的犹豫和集体努力，以扩大中西部和东南的HPV疫苗接种是公共卫生的重中之重，尤其是考虑到这两个地区都诊断出所有口咽癌病例中有50％以上。”

UTHealth休斯顿coauthors include Yenan Zhu, MS; David R. Lairson, PhD; Bijal A. Balasubramanian, MBBS, PhD; and Ruosha Li, PhD. Anna R. Giuliano, PhD, of the Moffitt Cancer Center, Tampa, Florida, was also a coauthor.

该研究的标题为“ 2001 - 2017年美国所有50个州的口咽癌发病率和死亡率趋势”，该研究得到了国家癌症研究所（R01CA232888）的支持，以及美国国立卫生研究院少数群体健康与健康差异（K01MD016440）。

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