杨刘博士

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beplay苹果手机能用吗研究兴趣

beplay苹果手机能用吗研究信息

Physical exercise induces a profound alteration of energy metabolism in skeletal muscle as well as in other organs such as heart, liver, and adipose tissue, which contributes to its beneficial effects in combating metabolic diseases/syndromes and maintaining human health. For instance, a single bout of exercise can decrease the levels of blood glucose to the normal range in Type II diabetic patients, primarily through promoting uptake and utilization of glucose in skeletal muscle. Exercise also increases the breakdown of lipids (lipolysis) in adipose tissue and promotes fatty acid uptake and utilization in skeletal muscle and heart, which mediates its anti-obesity effects. A better understanding of energy metabolism regulation during exercise will shed lights on novel therapies for metabolic diseases and syndromes.

我们的实验室旨在识别和破译细胞途径，以调节骨骼肌和心脏运动过程中能量代谢。我们的研beplay苹果手机能用吗究将重点放在两种重要的细胞途径上，以控制运动诱导的能量代谢改变，AMP激活的蛋白激酶（AMPK）信号通路和自噬过程。AMPK是能量稳态的主要调节剂，并因细胞能量短缺而被激活。激活后，AMPK磷酸化其底物以增强能源生产并抑制能源消耗，这有助于恢复能量平衡。在运动过程中，AMPK在骨骼肌和心脏中被激活，并且在促进能量代谢适应中起着至关重要的作用。自噬是降解和回收不必要和功能失调的细胞成分的细胞过程。它通过消除有害的细胞内材料，并允许在能量应力条件（例如运动）下允许内部养分的内部来源来维持细胞稳态的重要作用。在运动过程中，自噬水平在骨骼肌和心脏中大大诱导，以促进能量代谢适应。AMPK信号传导和自噬是两个独立调节但相互连接的细胞途径。先前的研究表明，AMPK激活上调自噬。 Recently, we have established a novel link that certain autophagy proteins and complexes are required for the effective AMPK activation in skeletal muscle during exercise. We will combine biochemical, cell biology, and molecular biology approaches and animal models to further reveal the novel regulations of AMPK signaling and autophagy during exercise in skeletal muscle and heart as well as the potential interplay between these two pathways, with an ultimate goal of advancing our understanding of exercise-induced energy metabolism adaptation and providing new angles for the prevention and treatment of metabolic syndromes and diseases. Our lab also seeks to understand the regulation of energy metabolism in other physiological/pathological conditions, such as myocardial ischemia/reperfusion.

出版物

出版信息

• 刘y*，Nguyen PT，Wang X，Zhao Y，Meacham CE，Zou Z，Bordieanu B，Johanns M，Vertommen D，Wijshake T，May H，Xiao G，Shoji-Kawata S，Rider MH，Morrison SJ，Mishra P和Mishra P和Levine B和Levine B和Levine B和Levine B和。（2020）TLR9和Beclin 1串扰调节运动中的肌肉AMPK激活。自然。2月；578(7796):605-609. (* co-correspondence author ; article highlighted in Nat Rev Endocrinol 2020)
• Fernándezáf，Sebti S，Wei Y，Zou Z，Shi M，McMillan Kl，He C，Ting T，Liu Y，Chiang W-C，Marciano DK，Schiattarella GG，Bhagat G，Moe OW，Hu MC，Levine B.（2018）Beclin 1/Bcl-2自噬调节络合物的破坏可促进小鼠的长寿。自然。Jun; 558（7708）：136-140。
• Liu Y，Lai YC，Hill EV，Tyteca D，Carpentier S，Ingvaldsen A，Vertommen D，Lantier L，Foretz M，Dequiedt F，Courtoy PJ，Erneux C，Erneux C，Viollet B，Shepherd PR，Shepherd PR，TavaréJM，TavaréJM，Jensen J，Jensen J，Rider MH。（2013）3-磷酸5-激酶（Pikfyve）是参与骨骼肌中收缩刺激的葡萄糖摄取的AMPK靶标。Biochem J.10月15日; 455（2）：195-206。
• Liu Y, Vertommen D, Rider MH, Lai YC. (2013)大鼠骨骼肌收缩期间，雷帕霉素非依赖性S6K1和4E -BP1磷酸化的哺乳动物靶标。细胞信号。Sep;25(9):1877-86.
• Arshad M，Ye Z，Gu X，Wong CK，Liu Y，Li D，Zhou L，Zhang Y，Bay WP，Yu VC，Li P.（2013）RNF13无名指蛋白,调节内质的reticulum stress-induced apoptosis through the inositol-requiring enzyme (IRE1α)/c-Jun NH2-terminal kinase pathway.J Biol Chem。Mar 22; 288(12):8726-36.
• 莱YC，Liu Y，Jacobs R，Rider MH。（2012）A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle.Biochem j。10月1日; 447（1）：137-47。
• ye J，李JZ*，Liu Y*，li X，Yang T，Ma X，Li Q，Yao Z，Li P.（2009）CIDEB是一种ER和脂质液滴相关的蛋白，通过与载脂蛋白B相互作用来介导VLDL脂化和成熟。Cell Metab。2月；9（2）：177-90。（*同等贡献）。