2. Blackburn Laboratory

Blackburn Laboratory

OVERVIEW

The laboratory ofDr. Spiros Blackburnis dedicated to advancing the understanding of subarachnoid hemorrhage (SAH) and cerebrovascular disorders such as cerebral aneurysm and to promote enhancements in treatments and therapies. It is our mission to conduct basic and translational research using interdisciplinary approach and techniques, promote enhancements in treatments and therapies, and improve the outcomes of patients affected by subarachnoid hemorrhage and vascular disorders.

Spiros Blackburn博士是休斯敦德克萨斯大学健康科学中心神经外科系的副教授，在那里他担任脑血管神经外科医生。他在UT Southwestern获得了医学博士学位，并在华盛顿大学和埃默里大学完成了实习和研究金。作为临床医生，他参加了许多临床试验和临床研究，以提高对脑动脉瘤的理解，并有助于转化研究。beplay苹果手机能用吗有关布莱克本博士出版物的完整列表，click here.

当前的项目

Correlation between haptoglobin genotype and hypercoagulability and inflammation biomarkers after SAH
Haptoglobin has been indicated to cerebral vasospasm, delayed cerebral ischemia, and poor outcome of patient after SAH. We use human biological samples to validate haptoglobin as a predictor of clinical outcome post SAH, and investigate the correlation between inflammatory and hypercoagulability biomarkers and haptoglobin.

Cerebrovascular endothelial cell dysfunction in SAH
SAH已显示出诱导大脑内皮功能障碍的多方面调节机制。我们使用动物模型来确定炎症信号传导在内皮细胞功能障碍中的作用，研究负责影响血脑屏障完整性的内皮细胞损伤的信号传导事件，并分析内皮细胞信号传导在减弱SAH诱导的大脑功能障碍中的作用。

TEAM MEMBERS

Spiros Blackburn，医学博士，助理教授
Peeyush K Thankamani Pandit, Ph.D., Sr. Research Associate
Kanako Matsumura, B.S., Research Assistant
Alba Rubi Banegas, B.S., Research Assistant

CONTACT

Blackburn Laboratory
Department of Neurosurgery
The University of Texas Medical School-Houston

电话：713-500-6133
电子邮件：Spiros.Blackburn@uth.tmc.edu

SELECTED PUBLICATIONS

1. Leclerc JL, Blackburn S, Neal D, Mendez NV, Wharton JA, Waters MF, et al. Haptoglobin phenotype predicts the development of focal and global cerebral vasospasm and may influence outcomes after aneurysmal subarachnoid hemorrhage. Proc Natl Acad Sci U S A. 2015;112(4):1155-60.
2. Fargen KM, Blackburn S, Deshaies EM, Carpenter JS, Jabbour P, Mack WJ, et al. Final results of the multicenter, prospective Axium MicroFX for Endovascular Repair of IntraCranial Aneurysm Study (AMERICA). J Neurointerv Surg. 2015;7(1):40-3.
3. Blackburn SL, Abdelazim AM, Cutler AB, Brookins KT, Fargen KM, Hoh BL, et al. Endovascular and Surgical Treatment of Unruptured MCA Aneurysms: Meta-Analysis and Review of the Literature. Stroke Res Treat. 2014;2014:348147.
4. Blackburn SL, Kadkhodayan Y, Ray WZ, Zipfel GJ, Cross DT, Moran CJ, et al. Onyx is associated with poor venous penetration in the treatment of spinal dural arteriovenous fistulas. J Neurointerv Surg. 2014;6(7):536-40.
5. Blackburn SL，Kadkhodayan Y，Shekhtman E，Derdeyn CP，Cross DT，Moran CJ。水平PCA的基底尖端动脉瘤治疗PCA支架辅助盘绕：病例系列。J NeuroInterv Surg。2013; 5（3）：212-6。
6. Kadkhodayan Y, Rhodes N, Blackburn S, Derdeyn CP, Cross DT, Moran CJ. Comparison of Enterprise with Neuroform stent-assisted coiling of intracranial aneurysms. AJR Am J Roentgenol. 2013;200(4):872-8.
7. Kadkhodayan Y, Shetty VS, Blackburn SL, Reynolds MR, Cross DT, Moran CJ. Pipeline embolization device and subsequent vessel sacrifice for treatment of a bleeding carotid pseudoaneurysm at the skull base: a case report. J Neurointerv Surg. 2013;5(5):e31.
8. Dhar R, Scalfani MT, Blackburn S, Zazulia AR, Videen T, Diringer M. Relationship between angiographic vasospasm and regional hypoperfusion in aneurysmal subarachnoid hemorrhage. Stroke. 2012;43(7):1788-94.
9. Blackburn SL, Ashley WW, Rich KM, Simpson JR, Drzymala RE, Ray WZ, et al. Combined endovascular embolization and stereotactic radiosurgery in the treatment of large arteriovenous malformations. J Neurosurg. 2011;114(6):1758-67.
10. Ray WZ，Strom RG，Blackburn SL，Ashley WW，Sicard GA，Rich KM。亚蛛网膜下腔出血后深静脉血栓形成的发生率。J Neurosurg。2009; 110（5）：1010-4。