2. Laboratory of Laura A. Smith Callahan, Ph.D.

Laboratory of Laura A. Smith Callahan, Ph.D.

OVERVIEW

史密斯·卡拉汉（Smith Callahan）实验室专注于开发的组织工程方法，用于使用涉及细胞，分子和干细胞生物学，化学和材料科学的技术的跨学科方法，用于脊髓损伤，脑外伤和软骨缺陷的临床治疗方法。利用工程方法，实验室试图优化脚手架设计和临床相关细胞来源的扩展。

神经外科系的助理教授，史密斯·卡拉汉博士earned her doctorate in Biomedical Engineering from the University of Michigan, where her work under focused on the effects of nanofibrous scaffolding on the osteogenic differentiation of embryonic stem cells. Upon completion of her thesis, she was awarded a post-doctoral fellowship on the Regenerative Science T90 training grant which allowed her to further study the effects of nanofibrous scaffolding on the neural differentiation of embryonic stem cells. To obtain additional training in peptide and polymer chemistry and soft material characterization, Dr. Smith Callahan transitioned to a post-doctoral position at the Institute of Polymer Science at the University of Akron with Matthew L. Becker. At the University of Akron, her work focused on the effects of bioactive peptides and gradient hydrogels on stem cell differentiation to mesenchymal and neuronal lineages.

Laura Smith-Callahan

当前的项目

1) Development of multi-component scaffolds to facilitate tissue regeneration through better replication of the native extracellular matrix.

2) Optimization of culture surfaces for the differentiation of human induced pluripotent stem cells to neural stem cells and oligodendrocyte progenitor cells.

3）使用组合方法鉴定最佳人工基质特性，例如生物活性信号部分浓度或机械性能。

4）合成用于脊髓，大脑和椎骨修复的新型生物材料的合成。

TEAM MEMBERS

Hiran Perera, Postdoctoral Research Fellow
Xi (Henry) Lu, Postdoctoral Research Fellow

CONTACT

电子邮件：Laura.A.SmithCallahan@uth.tmc.edu
Office Phone:713.500.3431

最新出版物Laura Smith-Callahan Lab

  1. Smith Callahan LA, Ganios AM, McBurney DL, Dilisio MF, Weiner, SD, Horton Jr WE, Becker ML.
    ECM Production of Primary Human and Bovine Chondrocyte in Hybrid PEG Hydrogels Containing Type I Collagen and Hyaluronic Acid.Biomacromolecules。13(5): 1625-1631, 2012.
  2. Zheng J,Smith Callahan LA, Hao J, Guo K, Wesdemiotis C, Weiss RA, Becker ML. (2012) Strain-Promoted Cross-Linking of PEG-Based Hydrogels via Copper-Free Cycloaddition.ACS Macro Letters。1:1071-1073, 2012.
  3. Stakleff KS, Lin F,Smith Callahan LA, Wade MB, Esterle A, Miller J, Graham M, Becker ML. Resorbable, Amino acid-based Poly(ester urea)s Crosslinked with Osteogenic Growth Peptide (OGP) with Enhanced Mechanical Properties and Bioactivity.Acta Biomaterialia。9 (2): 5132–5142, 2013.
  4. Smith Callahan LA, Ganios AM, Childers EP, Weiner, SD, Becker ML. Primary Human Chondrocyte Extracellular Matrix Formation and Phenotype Maintenance using RGD derivatized PEGDM Hydrogels Possessing a Continuous Gradient in Modulus.Acta Biomaterialia。9（4）：6095–6104，2013。
  5. Smith Callahan LA§, Ma Y §, Stafford CM, Becker ML. Concentration Dependent Neural Differentiation and Neurite Extension of mouse ESC on Primary Amine-derivatized Surfaces.生物材料科学。1(5):537-544, 2013. § both authors contributed equally to the work.
  6. Smith Callahan LA, Childers EP, Benard, SL, Weiner, SD, Becker ML. Maximizing Phenotype Constraint and ECM Production in Primary Human Chondrocytes Using RGD Concentration Gradient Hydrogels.Acta Biomaterialia。9 (7): 7240-7428, 2013.
  7. Smith Callahan LA，Policastro GM，Benard SL，Childers EP，Boettcher RM，Becker ML。离散和连续培养条件对RGD浓度梯度水凝胶中人间充质干细胞谱系选择的影响。Biomacromolecules。14(9): 3047-3054, 2013.
  8. Smith Callahan LA, Xie S, Barker IA, Zheng J, Dove AP, Becker ML. Directed Differentiation and Neurite Extension of mouse Embryonic Stem Cell on Aligned Poly(lactide) Nanofibers Functionalized with YIGSR Peptide.Biomaterials。34(36): 9089-9095, 2013.
  9. Policastro GM, Lin F,Smith Callahan LA, Esterle A, Graham M, Sloan Stakleff K, Becker ML. OGP Functionalized Phenylalanine-based Poly(ester urea) for Enhancing Osteoinductive Potential of human Mesenchymal Stem Cells. Biomacromolecules. 16 (4): 1358–1371, 2015.
  10. Yang Y-H, Kahn Z, Ma C, Lim HJ,Smith Callahan LA。Optimization of adhesive conditions for neural differentiation of murine embryonic stem cells using hydrogels functionalized with continuous
    Ile-Lys-Val-Ala-Val concentration gradients. Acta Biomaterialia. 21: 55-62, 2015.
  11. 史密斯·卡拉汉·洛杉矶。组合方法/高吞吐量策略用于组织工程应用中的水凝胶优化。Gels。2：18，2016。
  12. Lim HJ，Perera TH，Wilems T，Ghosh S，Zheng YY，Azhdarinia A，Cao Q，Smith Callahan LA。在神经分化和脊髓损伤的啮齿动物模型中，在独立的修饰部位上对双官能化透明质酸的反应。材料化学杂志B.印刷中。doi：10.1039/c6TB01906D