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PhD, Infectious Disease Immunology | Johns Hopkins University, Baltimore, MD
Postdoctoral Fellow, Viral Immunology | The University of Pennsylvania School of Medicine, Philadelphia
Postdoctoral Fellow, Cellular Immunology | Massachusetts Institute of Technology, Center for Cancer Research, Boston, MA
Research Associate, Cellular and Molecular Immunology | Scripps Clinic and Research Foundation, La Jolla, CA
Klein博士是诊断和生物医学科学系的免疫学教授。他是众多研究奖的获得者，包括Uthealth牙科学院发现奖学金的beplay苹果手机能用吗院长卓越奖，以及Crohn's and Colitis of America的研究奖。他曾在美国国立卫生研究院，美国癌症协会和国家科学基金会的研究部分工作。他是编辑委员会成员Scientific Reports, Developmental and Comparative Immunology,andCritical Immunology Reviews, and served as an associate editor for theJournal of Immunology. He has been an ad-hoc reviewer for more than 40 scientific journals, including forNature, Science, The Journal of Experimental Medicine, andThe Proceedings of the National Academy of Sciences. Dr. Klein’s research was continually funded for 26 years by the National Institute of Diabetes, Digestive, and Kidney Diseases of the NIH. He is the author of over 100 peer-reviewed publications.
Klein博士的实验室有两个主要的as of research. The first focuses on understanding basic immunobiological properties that regulate mammalian T cell responses in both healthy and diseased conditions, particularly as they relate to mucosal sites in the intestine and the oral cavity. The goal of these studies is to understand factors that activate the immune response in normal homeostatic settings in response to infection or cancer, as well as to define how chronic inflammation is perpetuated and how it can be curtailed, with particular emphasis on diseases such as inflammatory bowel disease, Crohn’s disease, and ulcerative colitis.
A second area of research in Dr. Klein’s laboratory is aimed at understanding the bilateral nature, function, and integration of the immune system and the endocrine system. This work has been instrumental in defining how the endocrine system regulates the immune response on the one hand, and reciprocally how the immune system contributes to systemic host metabolic activity. Dr. Klein’s laboratory identified the first alternatively-spliced form of thyroid stimulating hormone (TSH), and demonstrated that it is produced almost exclusively by cells of the immune system. Evidence from other laboratories has now link the expression of the TSHβ splice variant to the development of autoimmune thyroiditis, thus identifying a potential causative relationship between immune system TSH and chronic thyroid inflammation in Hashimoto’s thyroiditis and Graves’ disease.
Selected Publications: