Education

博士后研究员
Cambridge University & University of Reading
Ph.D.
University of California

Areas of Interest

Research Interests

Pathogenesis of hypertension and hypertensive end organ disease

Research Information

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In spite of much progress, cardiovascular disease remains the leading cause of mortality and chronic disability in our society. High blood pressure (hypertension) is a major force creating cardiovascular disease by causing or exacerbating injury to the blood vessels (atherosclerosis), the heart (heart failure), the brain (stroke) and the kidney (progressive renal disease). The impact of these diseases on public health is often underappreciated. For example, progressive kidney disease resulting in insufficient renal function consumes nearly 7% of all US government Medicare spending (an amount equal to the annual budget of NASA) and causes as many deaths each year as breast and prostate cancer combined.

心血管疾病的一部分是遗传的。引起疾病的映射基因的进展引起了人们的兴奋，即可以使用遗传方法更充分地理解心血管疾病。但是，继承并不简单，不能归因于单个基因。此外，包括遗传风险在内的风险在造成破坏力的基因之间分配（在广泛的人群中，这主要是指升高血压的人）和有助于器官抵抗伤害的能力的基因。损伤易感性的遗传轮廓的定义很差。关于血压升高（高血压）风险的遗传学知之甚少。然而，在过去的十年中，基因映射方法努力识别高血压基因，对发病机理的见识几乎没有影响。尽管人口中的GWAS方法取得了很小的成功，但他们在他们的现象中留下了“缺失遗传力”的现象，该现象引发了有关遗传因素在这些常见疾病中的作用的假设的问题。

Our work focuses on animal models of cardiovascular disease that offer tractable opportunities for investigation. We use genetic, genomic and systems biology approaches to understand the pathogenesis of hypertension and hypertensive end organ disease.

Publications

Publication Information

参考

  • Herring，S.M。，N。Gokul，M。Monita，R。Bell，E。Boerwinkle，S.E。Wenderfer，M.C。布劳恩和P.A.多丽丝。大鼠免疫球蛋白基因座与血清IgG水平和蛋白尿有关。J. Amer. Soc. Nephrol。In Press.
  • Bell，R.，S.M.Herring，N。Gokul，M。Monita，M.L。格罗夫，E。Boerwinkle，P.A.Doris。High resolution identity by descent mapping uncovers the genetic basis for blood pressure differences between SHR lines.循环（心血管遗传学）。In Press.
  • 多丽丝, P.A.血压和高血压的遗传学：稀有变体的作用。Cardiovasc. Ther。2010. In Press. PMID: 21129164.
  • R.I. Dmitrieva, C.A. Hinojos, M. Grove, R.J. Bell, E. Boerwinkle, M. Fornage andP.A.多丽丝。Genome-wide identification of allelic gene expression in hypertensive rats.循环（心血管遗传学）2:106-115, 2009
  • 多丽丝, P.A.促进钠重吸收的调节基因变异。高血压, 52:623-4, 2008.
  • Tian, D, R.I. Dmitrieva,P.A.多丽丝, J.F. Crary, R. Sondhi, T.C. Sacktor, P.J. Bergold. Protein kinase M zeta regulation of Na/K ATPase: A persistent neuroprotective mechanism of ischemic preconditioning in hippocampal slice cultures.Brain Res.1213C:127-139, 2008
  • R.I. Dmitrieva, C.A. Hinojos, E. Boerwinkle, M.C. Braun, M. Fornage andP.A.多丽丝。高血压肾病中的HNF1。高血压。51:1583-1589, 2008
  • M.J. Corenblum, V.E. Wise, K. Georgi, B.D. Hammock,P.A.多丽丝, M. Fornage. Effects of Ephx2 polymorphism on brain soluble epoxide hydrolase gene expression and function and risk of brain vascular disease in the stroke-prone spontaneously hypertensive rat.高血压51:1-7, 2008
  • 问：魏，P.A.多丽丝, M.V. Pollizotto, E. Boerwinkle, D.R. Jacobs, D.S. Siscovick, M. Fornage. Sequence Variation in the Soluble Epoxide Hydrolase (EPHX2) Gene and Subclinical Coronary Atherosclerosis. Interaction with Cigarette Smoking.动脉粥样硬化, 190:26-34, 2007.
  • M. Fornage andP.A.多丽丝。Genomics and Epigenomics of Hypertension.Curr. Opin. Molec. Therap.8:206-214, 2006.
  • Zhong, C., Liu, D., Haviland, P.A. Doris, and B.B. Teng. Simultaneous Expression of Apolipoprotein B mRNA Editing Enzyme and Scavenger Receptor BI Mediated by a Therapeutic Gene Expression System.动脉粥样硬化。184:264-75, 2006
  • P.A.多丽丝。The sodium-hydrogen exchange system. In “Sodium in Health and Diseases” M. Burnier, Editor. Marcel Dekker, N.Y. 2006.
  • M. Fornage, C.R. Lee,P.A.多丽丝， 多发性硬化症。布雷，K.E。North，G。Heiss，D.C。Zeldin和E. Boerwinkle。可溶性环氧化物水解酶基因具有与易感性和免受入射缺血性中风的敏感性相关的序列变化。Hum. Mol. Genetics14:2829-37, 2005
  • A. Kalsotra，X。Cui，S。Anakk，C.A。Hinojos，P.A.多丽丝和H. W. Strobel。在三个自发性高血压大鼠的三个亚链条中，细胞色素P450 4F的肾脏定位，表达和发育调节。Biochem. Biophys. Res. Comm.338:423-31 2005.
  • P.A.多丽丝。Na+, K+- ATPase和高血压。在：“全面的高血压”，JE Hall和G Lip，纽约Elsevier的编辑。2005。
  • C. A. Hinojos, E. Boerwinkle, M. Fornage andP.A.多丽丝。Combined genealogical, mapping and expression approaches to identify SHR hypertension candidate genes.高血压45: 698-704, 2005.
  • P.A.多丽丝and M. Fornage. The transcribed genome and the heritable basis of essential hypertension.Cardiovasc. Toxicol。5：95-108，2005
  • R.I. Dmitreiva，E。Lalli和P.A.多丽丝。通过多巴胺和PKA信号传导调节肾上腺皮质激素类固醇的产生。正面。Biosci。10:2489-2495, 2005.