Research Information

Neural And Molecular Bases Of Learning And Memory

该实验室beplay苹果手机能用吗的研究兴趣是学习和记忆的基础神经元和分子机制。海洋软体动物加州Aplysiais being used as a model system. InAplysiawe are studying mechanisms of implicit (nondeclarative) memory associated with simple forms of learning such as habituation, sensitization, classical or Pavlovian conditioning and operant conditioning.

各种各样的分子、生化、生物物理electrophysiological and imaging techniques are used to analyze the properties of the neural circuits and the individual neurons.

经验分析与现实的数学建模相辅相成，以确定观察到的过程及其相互作用的程度足以解释系统的行为。

神经回路示意图的图像

出版物

出版信息

Selected Papers from PubMed

  • Byrne, JH, Kandel, ER. (1996) Presynaptic facilitation revisited: State and time dependence.J.神经科学, 16(2): 425-435.
  • Zhang, F, Endo, S, Cleary, LJ, Eskin, A, Byrne, JH. (1997) Role of transforming growth factor-ß in long-term synaptic facilitation inAplysia。Science, 275:1318-1320.
  • Smolen，P，Baxter，DA，Byrne，JH。（2000）基因网络的数学建模。Neuron, 26:567-580.
  • Brembs，B，Lorenzetti，FD，Reyes，FD，Baxter，DA，Byrne，JH。（2002）操作者的奖励学习Aplysia：神经元相关和机制。Science, 296:1706-1709.
  • Angers，A，Fioravante，D，Chin，J，Cleary，LJ，Bean，AJ，Byrne，JH。（2002）5-羟色胺刺激的磷酸化Aplysiasynapsin and alters its subcellular distribution in sensory neurons.J. Neurosci., 22:5412-5422.
  • Mohamed，Ha，Yao，W，Fioravante，D，Smolen，P，Byrne，JH。（2005）cAMP响应元素aplysia creb1，creb2，andap-uchpromoters.生物化学杂志, 280: 27035-27043.
  • Smolen，P，Baxter，DA，Byrne，JH。(2006) A model of the roles of essential kinases in the induction and expression of late long-term potentiation.生物物理杂志，90：2760-2775。
  • Fukushima，T，Liu，Ry，Byrne，JH。（2007）转化生长因子-β2调节突触功效和可塑性，并诱导海马神经元中CREB的磷酸化。Hippocampus, 17:5-9.
  • Antzoulatos，例如，伯恩，JH。（2007年）长期致敏训练会导致尖峰变窄Aplysia感觉神经元。J.神经科学, 27:676-683.
  • Song, H, Smolen, P, Av-Ron, E, Baxter, DA, Byrne, JH. (2007) Dynamics of a minimal model of interlocked positive and negative feedback loops of transcriptional regulation by cAMP-responsive element binding proteins.Biophysical Journal, 92:3407-3424.
  • Fioravante，D，Liu，RY，Netek，A，Cleary，LJ，Byrne，JH。（2007）突触素调节基础突触强度，突触抑制和5-羟色胺诱导的感觉运动突触的促进。Aplysia。J.神经生理学, 98:3568-3580.
  • Smolen，P，Baxter，DA，Byrne，JH。（2008）Bissable MAP激酶活性：有助于维持晚期增强的合理机制。Am. J. of Physiology-Cell Physiology, 294: C503–C515.
  • Lorenzetti，F.D.，Baxter，D.A。和伯恩（J.H.）操作奖励学习的细胞类似物的分子机制。Neuron,59：815-828，2008。NIHMSID＃70417。
  • Mozzachiodi，R.，Lorenzetti，F.D.，Baxter，D.A。和Byrne，J.H。神经元兴奋性的变化是操作条件的长期记忆机制。Nature Neuroscience，11：1146-1148，2008。
  • Fioravante，D.，Liu，R.Y。和伯恩（J.H.）泛素 - 蛋白酶体系统对于长期突触抑制是必要的Aplysia。J.神经科学。28：10245-10256，2008。NIHMSID＃72703。
  • Mozzachiodi，R。和Byrne，J.H。不仅仅是突触可塑性：非突触可塑性在学习和记忆中的作用。Trends in Neurosciences33：17-26，2010年。NIHMS＃157344，PMID 19889466。
  • Zhang, Y., Smolen, P.D., Baxter, D.A. and Byrne, J.H. The sensitivity of memory consolidation and reconsolidation to inhibitors of protein synthesis and kinases: Computational analysis.Learning and Memory, 17: 428-439, 2010.
  • Liu，R.Y.，Shah，S.，Cleary，L.J。和Byrne，J.H。5-羟色胺和训练引起的CREB2动态调节Aplysia。Learning and Memory, 18:245-249, 2011.
  • Liu, R.Y., Cleary, L.J. and Byrne, J.H. The requirement for enhanced CREB1 expression in consolidation of long-term synaptic facilitation and long-term excitability in sensory neurons ofAplysia。J.神经科学, 31:6871-6879, 2011.
  • Lorenzetti，F.D.，Baxter，D.A。和伯恩（J.H.）经典调节类似物增强了乙酰胆碱反应，但降低了鉴定神经元的兴奋性。J.神经科学，31:14789-14793, 2011. PMCID: PMC3198865.
  • Hart, A.K., Fioravante, D., Liu, R.Y., Phares, G.A., Cleary, L.J., and Byrne, J.H. Serotonin-mediated synapsin expression is necessary for long-term facilitation of theAplysiasensorimotor synapse.J.神经科学，31:18401-1841, 2011. PMID#22171042, NIHMSID#347966.
  • Zhang，Y.，Liu，R.Y.，Heberton，G.A.，Smolen，P.D.，Baxter，D.A.增强学习方案的计算设计Nature Neuroscience,15:294-297, 2012. PMID#22197829.
  • Liu，R.Y.，Zhang，Y.，Baxter，D.A。Smolen，P.，Cleary，L.J。和Byrne，J.H。长期突触可塑性的赤字是通过计算预测的刺激方案挽救的。J.神经科学，33:6944-6949, 2013.
  • Liu, R.Y., Zhang, Y. Coughlin, B., Cleary, L. and Byrne, J.H. Doxorubicin attenuates serotonin-induced long-term synaptic facilitation by phosphorylation of p38 mitogen-activated protein kinase.J.神经科学, 34:13289-13300, 2014. PMCID: PMC4180468.
  • Byrne, J.H. and Hawkins, R.D. Nonassociative learning in invertebrates.Cold Spring Harbor Perspectives in Biology, 7:a021675, 2015. PMCID: PMC4448621.
  • Hawkins, R.D. and Byrne, J.H. Associative learning in invertebrates.Cold Spring Harbor Perspectives in Biology, 7:a021709, 2015. PMCID: PMC4448622.
  • Smolen, P., Zhang, Y. and Byrne, J.H. The right time to learn: mechanisms and optimization of spaced learning.Nature Reviews Neuroscience, 17:77-88, 2016. PMCID: PMC5126970.
  • Smolen，P.，Baxter，D.A。和伯恩（J.H.）回忆如何持续几天，几年或一生？提出的维持突触增强和记忆力的机制。Learning & Memory，26：133-150，2019。PMID：30992383。
  • Liu, R.Y., Zhang, Y., Smolen, P., Cleary, L.J. and Byrne, J.H. Role of p90 ribosomal S6 kinase in long-term synaptic facilitation and enhanced neuronal excitability.Scientific Reports,10：608，2020。
  • Costa，R.M.，Baxter，D.A。和伯恩（J.H.Learning & Memory，27：236-249，2020。PMID：32414941。
  • Smolen P., Wood M.A., Baxter D.A., and Byrne J.H. Modeling suggests combined-drug treatments for disorders impairing synaptic plasticity via shared signaling pathways.计算神经科学杂志，2020年。DOI10.1007/S10827-020-00771-4。
  • Smolen P.，Baxter D.A.和Byrne J.H.比较维持LTP和长期记忆的理论：激酶反馈途径和突触重新激活的角色的计算分析。计算神经科学领域。2020. DOI 10.3389/fncom.2020.569349.