Stroke Research
- Prevention Clinical Trials
- Recovery Trials
- 急性缺血性中风试验
- Acute Brain Hemorrhage Trials
- Subarachnoid Hemorrhage Trials
Stroke Prevention Trials
START – Optimal Delay Time to Initiate Anticoagulation after Ischemic Stroke in Atrial Fibrillation
Investigator:Abdelhamid, Noureldin
Lead CR:Cooksey, Gabretta
SLEEP-SMART – Sleep for Stroke Management and Recovery Trial
Investigator:马里兰州Sudha Tallavajhula和Anjail Sharrief, MD
Lead CR:Cohen, Audrey S
Sleep apnea in TIA/AIS.
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ARCADIA – AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke
Investigator:Anjail Sharrief, MD
Lead CR:Cooksey, Gabretta
Summary non- lacunar with atrial cardiopathy.
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STOP STROKE – Stroke Telemedicine Outpatient Prevention Program for Blood Pressure Reduction
Investigator:Sharrief, Anjail
Lead CR:Cooksey, Gabretta
Ischemic and hemorrhagic stroke.
Enrollment Status:Actively enrolling
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AXIOMATIC – A Study on BMS-986177 for the Prevention of a Stroke in Patients Receiving Aspirin and Clopidogrel
Investigator:Sharrief, Anjail
Lead CR:Cohen, Audrey S
Factor XIa inhibitor in non-lacunar AIS or TIA.
Enrollment Status:Enrollment beginning in the near future.
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WVACHII obs – Registry for Women’s Vascular and Cardiac Health Interdisciplinary Initiative
Investigator:Gonzales, Nicole R
Lead CR:Tulod, Kathleen B
Enrollment Status:Actively enrolling
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Recovery Trials
PREDICT – ICH obs – Predicting Upper Extremity Motor Recovery in Subcortical Hemorrhagic Stroke Using DTI and TMS
Investigator:Sean Savitz, MD (Zafer/Shayan/Aronowski)
Lead CRC:Dorothea Parker
Diagnostics TMS in ICH
LAPHI obs – Lesion size and Brain Atrophy changes in Patients with Hemorrhagic and Ischemic Stroke (LAPHI)
Investigator:Muhammad Haque, MD
Lead CRC:George, Sarah
Summary Assessment of MRI after stroke
TRANSPORT-2 – TRANScranial direct current stimulation for Post-stroke motor Recovery – a phase II study
Investigator:Gerard Francisco, MD
Lead CRC:Parker, Dorothea M
Purpose:Upper extremity recovery after ischemic stroke
Key Inclusion Criteria:1st ever, unilateral ischemic stroke; at least 10 degrees of wrist extension
tDCS+CIMT for with 6 months of 1st ever, unihemispheric AIS.
PISCES – A Randomized, Placebo-Controlled Study of the Efficacy and Safety of Intracerebral Stem Cells (CTX0E03 DP) in subjects with Disability Following an Ischemic Stroke
Investigator:Savitz, Sean I
Lead CRC:Dorothea Parker
Purpose:Motor recovery
Key Inclusion Criteria:ischemic stroke, wrist extension and shoulder shrug present
Enrollment Status:Actively enrolling
Summary IV Stem cell therapy for chronic IS
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iACQUIRE – Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation
Investigator:Nivedita Thakur, MD
Lead CRC:Dorothea Parker
Purpose:Recovery of upper extremity weakness in neonatal stroke
Key Inclusion Criteria:8-36 months with unilateral upper extremity deficit
In-home CIMT in chronic pediatric AIS.
Enrollment Status:Actively enrolling
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Study Name VAST-rehab (Obs) – Virtually Assisted home rehabilitation after Acute Stroke
Investigator:Sean Savitz, MD
Lead CRC:Dorothea Parker
Summary Home-based telerehab after acute stroke (AIS / ICH)
Enrollment Status:On hold
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COPOR Obs Clinical Outcome and Patient Factors in Patient’s outcomes admitted to inpatient rehabilitation facility
Investigator:Sean Savitz, MD
Lead CRC:Dorothea Parker
Purpose:Evaluating the effect of IPR on stroke recovery
Key Inclusion Criteria:admitted to IPR facility within MH system
Retrospective analysis of inpatient rehab and recovery data
Enrollment Status:Actively enrolling
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EnRICH – Efficient Resource Utilization for Patients with Intra Cerebral Hemorrhage
Investigator:Sean Savitz, MD
Lead CRC:Dorothea Parker
Assesses regional patterns of care for ICH
Enrollment Status:Actively enrolling
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NCS-01
Investigator:Anjail Sharrief, MD
Lead CRC:Dorothea Parker
Purpose:Recovery
Key Inclusion Criteria:Ischemic stroke; NIHSS 6-18 w/ or w/o TPA/IAT (maintains score after intervention); pre-stroke mRS <3; LSN < 32 hours from planned infusion
Assesses regional patterns of care for ICH
Enrollment Status:Actively enrolling
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BIONICS
Investigator:Sean Savitz, MD
Lead CRC:Dorothea Parker
Purpose:Machine learning
Key Inclusion Criteria:Cleared to participate in rehab activity
Enrollment Status:Actively enrolling
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Acute Ischemic Stroke (AIS)
MOST – Multi-arm Optimization of Stroke Thrombolysis
Investigator:Barreto, Andrew D
Lead CRC:Franklin, Jamey D
Argatroban or eptifibatide IV after tPA for AIS
Enrollment Status:Actively Enrolling
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SELECT-2 – A Randomized Controlled Trial to Optimize Patient’s Selection for Endovascular Treatment in Acute Ischemic Stroke
Investigator:Amrou Sarraj, MD
Lead CRC:Pujara, Deep K
EVT for large core
Enrollment Status:Actively Enrolling
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TESLA – Thrombectomy for Emergent Salvage of Large Anterior Circulation
Ischemic Stroke
Investigator:Sunil Sheth, MD
Lead CRC:Lopez Rivera, Victor S
EVT for large core
Enrollment Status:Actively Enrolling
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SEGA – Sedation Versus General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke
Investigator: Peng R. Chen, MD
Lead CRC:Ambrocik, Alexander
GA or Conscious sedation during EVT for anterior circulation large vessel occlusions
Enrollment Status:Actively Enrolling
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ZODIAC – Zero degree head positioning in hyperacute large artery ischemic Stroke
Investigator:Gonzales, Nicole R
Lead CRC:Tulod, Kathleen B
Large artery ischemic stroke
Enrollment Status:Actively Enrolling
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TIMELESS – Tenecteplase in Stroke Patients Between 4.5 and 24 Hours
Investigator:Andrew Barreto, MD
Lead CRC:Franklin, Jamey D
TNK after AIS
Enrollment Status:Actively Enrolling
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Intrepid – Impact of Fever Prevention in Brain Injured Patients
Investigator:HuiMahn Alex Choi, MD
Lead CRC:Glenda L Torres
IS, ICH, SAH
Enrollment Status:Actively Enrolling
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Stroke (AIS) Bio-Repository
Investigator:Aronowski, J
Lead CRC:Satani, Nikunj
Biorepository of specimens including blood, CSF and brain tissue
Enrollment Status:Actively Enrolling
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Acute Brain Hemorrhage Trials
FASTEST (start up pending) – Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial
Investigator:James Grotta
Lead CR:Bratina, Patti L
Enrollment Status:Actively Enrolling
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Novartis
Investigator:HuiMahn Alex Choi, MD
Lead CRC:Glenda Torres
Enrollment Status:Actively Enrolling
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Intrepid – Impact of Fever Prevention in Brain Injured Patients
Investigator:HuiMahn Alex Choi, MD
Lead CRC:Torres, Glenda L
AIS, ICH, SAH
Enrollment Status:Actively Enrolling
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CAA-ICH – Developing a Biochemical Test to Differentiate Cerebral Amyloid Angiopathy-Intracerebral Hemorrhage from Hypertensive Hemorrhage (obs)
Investigator:Gonzales, Nicole R
Lead CRC:Kathleen Tulod
Enrollment Status:Actively Enrolling
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Hemostasis obs
Investigator:Chang, Tiffany R
Lead CRC:Torres, Glenda L
Enrollment Status:Actively Enrolling
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Subarachnoid Hemorrhage Trials
PILLAR – Prospective Trial of Cerebrospinal Fluid Filtration After Aneurysmal
Subarachnoid Hemorrhage via Lumbar Catheter
Investigator:Spiros Blackburn
Enrollment Status:Actively Enrolling
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iVAST – The Intra-arterial Vasospasm Trial
Investigator:Peng R. Chen
Lead CR:Alexander Ambrocik
Comparing medication tx for vasospasms. In pt post surgery only.
Enrollment Status:Actively Enrolling
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Intrepid – Impact of Fever Prevention in Brain Injured Patients
Investigator:HuiMahn Alex Choi
Lead CR:Glenda L Torres
Enrollment Status:Actively Enrolling
Contact Us:To learn more about this trial,please fill out this short online form »
Mani bio-Repository
Investigators:Huimahn Alex Choi/Tiffany Chang
Lead CR:Glenda L Torres
Enrollment Status:Actively Enrolling
Contact Us:To learn more about this trial,please fill out this short online form »