Education

B.S.，生物学
New York University, 1968
M.S., Human Genetics and Genetics Counseling
University of Colorado Health Sciences Center, 1976
博士，流行病学
University of Texas School of Public Health, 1988

Areas of Interest

Clinical Interests

Medical Genetics, Orthopedic Genetic Disorders, Dwarfing Conditions, Craniofacial Disorders.

Research Interests

Gene discovery in cleft lip and palate, Role of mutant cartilage oligomeric matrix protein (MT-COMP) in pseudoachondroplasia.

Publications

Publication Information

Skeletal dysplasias/ Dwarfing conditions

Coustry, F., Posey, K.L., Maerz, T., Baker, K., Abraham, A.M., Ambrose, C.G., Nobakhti, S., Shefelbine, S.J., Bi, X., Newton, M., Gawronski, K., Remer, L., Veerisetty, A.C., Hossain, M.G., Chiu, F.,Hecht，J。T.: Mutant cartilage oligomeric matrix cartilage (COMP) compromises bone integrity, joint function and the balance between adipogenesis and osteogenesis. Matrix Biol., April 2018 PMID:29309831 PMCID: PMC5910205

Posey，K.L.，Coustry，F.，Veerisetty，A.C.，Hossain，M.G.，Gambello，M.J。，Hecht,J.T.: Novel mTORC1 mechanism suggest therapeutic targets for COMPopathies. Am J Pathol 2019 Jan;189(1):132-146. doi: 10.1016/j.ajpath.2018.09.008. PMID: 30553437 PMCID: PMC6412713

Hecht,J.T.，Coustry，F.，Veerisetty，A.C。，Hossain，M.G.，Posey，K.L。：白藜芦醇通过激活自噬来减少小鼠中的复杂性。J Bone Min Res Plus 2020 doi，org/10.1002/jbm4.10456

Hecht,J.T., Veerisetty, A.C., Wu, J., Hossain, M.G., Chiu, F., Gannon, F.H., Posey, K.L.: Primary OA phenotype induced by ER-stress is mitigated by resveratrol. Submitted Am J Pathol 2021

Hoover-Fong, J., Alade, A.Y., Hashmi, S.S.,Hecht，J.TLegare, J。,小,当,刘,C, McGready J。, Modaff, P., Pauli, R.M., Rodriguez-Buritica, D., Schulze, K., Serna E., Smil, C., Bober M.B.: CLARITY: Achondroplasia Natural History Study – a multi-center retrospective cohort study of achondroplasia. In press Genet Med J 2021

Cleft lip and palate gene discovery

Chiquet, B.T., Yuan, Q., Swindell, E.C., Maili, L., Plant, R., Dyke, J., Boyer, R., Teichgraeber, J.F., Greives, M.R., Mulliken, J.B., Letra, A., Blanton, S.H., Hecht, J.T.: Knockdown of Crispld2 in zebrafish identifies a novel network for nonsyndromic cleft lip with or without cleft palate candidate genes. doi: 10.1038/s41431-018-0192-5. Epub 2018 Jun 13 (10):1441-1450. Eur J Hum Genet. October 26, 2018 PMID: 29899370 PMCID: PMC6138754

Maili, L., Letra, A., Silva, R., Buchanan, E.P., Mulliken, J.B., Greives, M.R., Teichgraeber, J.F., Blackwell, S.J., Ummer, R., Weber, R., Chiquet, B., Blanton, S.H.,Hecht, J.T.:PBX-WNT-P63-IRF6 pathway in nonsyndromic cleft lip and palate. Birth Defects Res. 2020 Feb 1;112(3):234-244. doi: 10.1002/bdr2.1630. Epub 2019 Dec 11. PMID:31825181

Morris, V.E., Hashmi, S.S., Zhu, L., Urbina, C., Greives, M.R., Buchanan, E.P., Mulliken, J.B., Blanton, S.H., Zheng, W.J.,Hecht JT,莱特拉（Letra），a。：非同步裂口和pape的颅面增强剂的证据。Hum Genet，2020年4月，doi.org/10.1007/S00439-020-02169-9 PMID：32318854

Bishop，M.R.，Diaz Perez，K.K.，Sun，M.，Ho，S.，Chopra，P.，Mukhopadhyay，N.，Hetmanski，J.B.，J.B.，Taub，M.A.，C.P.，Wehby，G。，Hecht,J.T.,Deleyiannis, F., Weinberg, S.M., Wu-Chou, Y.H., Chen, P.K., Brand, H., Epstein, M.P., Ruczinski, I., Murrary, J.C., Beaty, T.H., Feingold, E., Lipinski, R.J., Cutler, D.J., Marazita, M.L.: Genome-wide Enrichment of De Novo Coding Mutations in Orofacial Cleft Trios doi.org/10.1016/j.ajhg.2020.05.018

Young, J., Lifer, S.S., Blanton, S.,Hecht, J.T。：DNA甲基化变异被鉴定出对非蛋白酶裂唇和pa的不一致的双胞胎双胞胎。提交的边境细胞开发生物2021

董事会认证

American Board of Medical Genetics, 1982 (M.S.)
American Board of Medical Genetics, 2009 (Ph.D.)
美国遗传咨询委员会，2003年（M.S.）