雷切尔·米勒（Rachel K. Miller），博士学位|麦戈文医学院

Education

学士学位，生物学和物理学: DePauw University，2001年
博士学位，遗传学和分子生物学: 埃默里大学，佐治亚州亚特兰大，2007年
Postdoctoral and Odyssey Fellow, Developmental and Cell Biology: 德克萨斯大学医学博士安德森癌症中心，德克萨斯州休斯敦，2007- 2012年；教练2012-2013

Areas of Interest

Research Interests

Although congenital anomalies of the kidney and urinary tract (CAKUT) are the predominant birth defects diagnosed in the prenatal period and are the most common cause of pediatric end stage renal disease, only 13% of cases have a known monogenic cause. CAKUT can result in defects in the formation of nephrons, which are required for the function of the kidney. During kidney development, early beta-catenin-mediated Wnt signaling, which is required for nephric mesenchyme condensation into epithelia, transitions to planar cell polarity (PCP)-mediated Wnt signaling, resulting in morphogenesis and differentiation of the nephron. A balance between beta-catenin and PCP signaling is thus critical in kidney formation and maintenance, with disruption of this balance promoting cystic diseases and kidney cancers. Our laboratory uses非洲爪蟾蜍(frog) embryos to understand how cells communicate via Wnt signaling to coordinate nephron formation and how this process goes awry giving rise to CAKUT.

Publications

Publication Information

View my Bibliography

(Selected Publications and Preprints)

爪蟾倾斜和小鼠跨肾上腺素之间细胞多样性的比较研究

Corkins ME, Achieng M, DeLay BD, Krneta-Stankic V, Cain MP, Walker BL, Chen J, Lindstrom NO, Miller RK.

Biorxiv [预印象]。2022年1月。

Tissue targeted CRISPR/Cas9-mediated genome editing of multiple homeologs in F₀generation非洲爪蟾蜍laevisembryos

Corkins ME, DeLay BD, Miller RK.

冷泉亨布尔.2021年12月15日.

Wnt/PCP Formin Daam1 Drives Cell-Cell Adhesion During Nephron Development

Krneta-Stankic V，Corkins ME，Paulucci-Holthauzen A，Kloc M，Gladden AB，Miller RK。

Cell Rep. 2021 Jul 6;36(1):109340.

Aquatic models of human ciliary diseases

Corkins ME, Krneta-Stankic V, Kloc M, Miller RK.

genesis. 2021 Feb;59(1-2):e23410.

Blackburn ATM，Bekheirnia N，UMA VC，Corkins ME，Xu Y，Rosenfeld JA，Bainbridge MN，Yang Y，Liu P，Madan-Khetarpal S，Delgado MR，Hudgins L，Hudgins L，Krantz I，Krantz I，Rodriguez-Buritica D，Wheeler PG，Wheeler PG，Wheeler PG，Wheeler PG，Wheeler PG，Wheeler PG，Wheeler PG，Gazali L，Al Shamsi A，Gomez-Ospina N，Chao H，Mirzaa GM，Scheuerle AE，Kukolich MK，Scaglia F，Eng C，Eng C，Willsey HR，Braun MC，Lamb DJ，Lamb DJ，Miller RK，Bekheirnia M.，Bekheirnia M.

基因医学。2019年12月; 21（12）：2755-2764。

Divergent roles of the Wnt/PCP formin Daam1 in renal ciliogenesis
Corkins ME, Krneta-Stankic V, Kloc M, McCrea PD, Gladden AB, Miller RK.

PLoS One, 2019 Aug 30;14(8):e0221698.

建模先天性肾脏疾病非洲爪蟾蜍laevis

布莱克本·ATM，米勒RK。

Dis Model Mech. 2019 Apr 9;12(4).

Dynamin binding protein is required for非洲爪蟾蜍laeviskidney development

延迟BD，Baldwin TA，Miller RK。

Front. Physiol., 26 February 2019.

Transgenic非洲爪蟾蜍laevisLine for In Vivo Labeling of Nephrons within the Kidney.

Corkins ME, Hanania HL, Krneta-Stankic V, DeLay BD, Pearl EJ, Lee M, Ji H, Davidson AJ, Horb ME, Miller RK.

基因。2018;9（4）。