Education

博士后研究员
McGovern Medical School, The University of Texas Health Science Center Houston, 2019
Ph.D.
Seoul National University College of Medicine, 2012

Areas of Interest

Research Interests

G蛋白介导的TRPC通道激活机制及其生理/病理意义

Research Information

瞬态受体电位典型（TRPC）蛋白是果蝇TRP通道的同源物。在哺乳动物中，有七个TRPC成员，在不同组织中具有广泛的生理和病理生理功能。TRPC通道是钙渗透性非选择性阳离子通道。当它们被打开或激活时，钠和钙通量进入细胞，从而导致膜电位（去极化）和细胞内钙浓度增加。研究表明，大多数TRPC通道的开放取决于通过GQ蛋白发出信号的G蛋白偶联受体的激活。最近，我们发现，对于TRPC4和TRPC5的激活，GQ和GI信号通路都涉及。

My current research focuses on elucidating the physiological relevance of TRPC4 channels. I have investigated the role of TRPC4 channel in neurons and found that TRPC4 plays an important role in dendritic development of hippocampal neurons via a Gi/Gq-dependent mechanism.

使用晚期荧光显微镜乳房分辨率成像技术，我确定了TRPC4在调节树突生长和稳定性中的新作用。这是通过通过TRPC4依赖的肌球蛋白轻链激酶对肌动蛋白细胞骨架结构进行的精细控制来发生的，这有助于稳定新开发的树枝状分支。这些观察结果表明了肌动蛋白 - 细胞骨架调节的一种新机制。

In addition to neurodevelopment function of G protein-mediated TRPC4 and other TRPC channel activities, I am also investigating the role of TRPC channels in ischemic neuronal death by excitotoxicity. The ischemic insults to the brain enhance glutamate release to induce membrane depolarization of neurons. TRPC channels can be a potential mediator of membrane excitability caused by metabotropic glutamate receptors capable of stimulating both Gq and Gi signaling pathways in neurons. I found that the genetic ablation ofTrpc4和Trpc1,4,5,6genes protected brain neurons from injury caused by ischemic stroke. This follows the bases for further mechanistic studies of TRPC-mediated neuronal cell death.

I will extend my research as follows:

  • To study the roles of TRPC4 and other TRPC channels in the regulation of cytoskeleton in neuronal and non-neuronal systems.
  • 研究TRPC通道在中风和神经系统疾病中的病理意义。

Publications

Publication Information

  • Jeon JP, Thakur DP, Tian JB, So I, Zhu MX. (2016).G蛋白信号传导和Goloco蛋白的调节剂通过作用于GαI/O抑制TRPC4通道功能。Biochem J。May 15;473（10）:1379-90。doi: 10.1042/BCJ20160214.Epub 2016 Mar 17.PubMed PMID: 26987813;PubMed Central PMCID: PMC5146954。
  • Thakur DP，Tian JB，Jeon JP，Xiong J，Huang Y，Flockerzi V，朱MX。（2016）。Critical roles of Gi/o proteins and phospholipase C-δ1 in the activation of receptor-operated TRPC4 channels.Proc Natl Acad Sci U S A。1月26日；113(4):1092-7。doi: 10.1073/pnas.1522294113.Epub 2016 Jan 11.PubMed PMID: 26755577;PubMed Central PMCID：PMC4743816。
  • Myeong J, Kwak M,Jeon JP, Hong C, Jeon JH, So I. (2015).Close spatio-association of the transient receptor potential canonical 4 (TRPC4) channel with Gαi in TRPC4 activation process.Am J Physiol Cell Physiol。6月1日；308（11）：C879-89。doi：10.1152/ajpcell.00374.2014。Epub 2015 Mar 18.PubMed PMID：25788576。
  • Jeon JP, Roh SE, Wie J, Kim J, Kim H, Lee KP, Yang D, Jeon JH, Cho NH, Kim IG, Kang DE, Kim HJ, So I. (2013).激活TRPC4βby Gαi subunit increases Ca2+ selectivity and controls neurite morphogenesis in cultured hippocampal neuron.Cell Calcium。Oct;54(4)：307-19。doi：10.1016/j.ceca.2013.07.006。Epub 2013 8月14日。PubMed PMID: 24011658。
  • Kim J, Kwak M,Jeon JP，Myeong J，Wie J，Hong C，Kim SY，Jeon JH，Kim HJ，So I.（2014）。规范瞬态受体电位（TRPC）1/4通道的同工型和受体特异性通道特性。pflugers拱门。;466(3):491-504。doi：10.1007/s00424-013-1332-y。Epub 2013 Aug 16.PubMed PMID：23948741。
  • Park SH, Ryu1 SY, Yu WJ, Han YE, Ji YS, Oh K, Sohn JW, Lim A,Jeon JP, Lee H, Lee KH, Lee SH, Berggren PO, Jeon JH, Ho WK. (2013). Leptin promotes KATP channel trafficking by AMPK signaling in pancreatic β-cells.Proc Natl Acad Sci U S A。Jul 30;110(31):12673-8.
  • 金正日H,Jeon JP，Hong C，Kim J，Myeong J，Jeon JH，So I.（2013）。PI（4,5）p（2）的重要作用在维持瞬态受体电位规范（TRPC）4β的活性。pflugers拱门。July; 465(7):1011-21. doi: 10.1007/s00424-013-1236-x. Epub 2013 Feb 17.
  • Kim H*, Kim J*,Jeon JP*，Myeong J, Wie J, Hong C, Kim HJ, Jeon JH, So I. (2012).The roles of G proteins in the activation of TRPC4 and TRPC5 transient receptor potential channels.频道(Austin)。sep-oct;6(5):333-43。doi: 10.4161/chan.21198.Epub 2012 Aug 10.Review.PubMed PMID：22878724;PubMed Central PMCID: PMC3508772。*equally contributed
  • Hong C，Kim J，Jeon JP, Wie J, Kwak M, Ha K, Kim H, Myeong J, Kim SY, Jeon JH, So I. (2012). Gs cascade regulates canonical transient receptor potential 5 (TRPC5) through cAMP mediated intracellular Ca2+释放和离子频道贩运。Biochem Biophys Res Commun.;421（1）：105-11。
  • Jeon JP*, Hong C*, Park EJ, Jeon JH, Cho NH, Kim IG, Choe H, Muallem S, Kim HJ, So I. (2012). Selective Gαi subunits as novel direct activators of transient receptor potential canonical (TRPC)4 and TRPC5 channels.J Biol Chem。;287(21):17029-39.*: equally contributed.
  • Sung TS*,Jeon JP*, Kim BJ*，Hong C，Kim SY，Kim J，Jeon JH，Kim HJ，Suh CK，Kim SJ，So I.（2011）。PKA依赖性抑制TRPC5通道的分子决定因素。Am J Physiol Cell Physiol.;301(4):C823-32.*: equally contributed.
  • Sung TS, Kim MJ, Hong S,Jeon JP, Kim BJ, Jeon JH, Kim SJ, So I. (2009). Functional characteristics of TRPC4 channels expressed in HEK 293 cells.Mol Cells.27(2):167-73.
  • Jeon JP，Lee KP，Park EJ，Sung TS，Kim BJ，Jeon JH，So I.（2008）。GI蛋白亚型对TRPC4的特异性激活。Biochem Biophys Res Commun。377(2):538-43.
  • Kim MJ,Jeon JP, Kim HJ, Kim BJ, Lee YM, Choe H, Jeon JH, Kim SJ, So I. (2008). Molecular determinant of sensing extracellular pH in classical transient receptor potential channel 5.Biochem Biophys Res Commun。365（2）：239-45。