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Dr. Do Monte received his bachelor’s degree in veterinary medicine from Universidade do Estado de Santa Catarina in Brazil (2002), and his master’s and PhD degrees (general pharmacology and neuropharmacology) from Universidade Federal de Santa Catarina in Brazil, under the mentorship of Dr. Antônio P. Carobrez. His master dissertation was directed to understand the mechanisms involved in the expression of both innate and learned fear memories (2006). His doctorate thesis was focused on elucidating the noradrenergic mechanisms mediating the extinction and reconsolidation of aversive memories (2010). As a postdoctoral fellow in Dr. Gregory Quirk’s laboratory in the Department of Psychiatry at the University of Puerto Rico, Dr. Do Monte investigated the neural circuits regulating the retrieval of fear memories and the crucial role of the passage of time in the reorganization of these memories. During his postdoctoral training, he was awarded the prestigious “NIH pathway to independence award (K99/R00)” from the National Institute of Mental Health. Dr. Do Monte became an Assistant Professor in the McGovern Medical School at UTH in 2016, where he has recently been awarded a Rising STARs Award from the UT System.

beplay苹果手机能用吗研究信息

The Do Monte Lab focuses on understanding the neural circuits and mechanisms underlying emotional memories. We are particularly interested in elucidating how fear- and reward-associated memories interact to generate the most adaptive behavioral responses. Using a multidisciplinary approach in rats, we combine optogenetic, in vivo electrophysiological recording, pharmacological, immunohistochemical, and imaging techniques to investigate the mechanisms involved in balancing fear and reward stimuli, with emphasis on the innate defensive responses induced by predator cues.

The mammalian brain has an exceptional ability to associate aversive and rewarding stimuli with environmental cues. The correct discrimination between harmful and beneficial stimuli allows an organism to select the most appropriate response, thereby protecting it from danger. In humans, inappropriate retrieval of reward associated memories is the framework for substance abuse, whereas inappropriate retrieval of fear/aversive memories can lead to the development of anxiety disorders. Understanding the neural circuits mediating the integration of fear- and reward-associated memories may uncover more effective therapies for patients suffering from both anxiety and substance-related addictive disorders.

Publications

Publication Information

  • Fernandez-León*, JA; Engelke*, DS; Aquino-Miranda*, G; Goodson, A;做蒙特，FH。Neural correlates and determinants of approach-avoidance conflict in the prelimbic prefrontal cortex。Under review. (available in bioRxivs2021.05.27.445881).view PDF
  • De Oliveira-Alvares, L and做蒙特，FH。Understanding the dynamic and destiny of memories.神经科学and Biobehavioral Reviews.125, 592-607, 2021.view PDF
  • Engelke, DS; Zhang, XO; O’Malley, J; Fernandez-Leon, JA; Li, S; Kirouac, GJ; Beierlein, M;做蒙特，FH。下丘脑 - 丘脑纹状体电路，可控制大鼠的避免进路冲突。Nature Communications。12(1):2517, 2021.view PDF
  • Chen, Y; Ma, N; Pei, Z; Wu, Z;Do Monte, FH;Keefel，S；Yellin，E；陈，M；Yin，J;Lee，G；小型托里比奥，a;hu，y;bai，y;韭葱; Quirk, GJ; Chen, G. A NeuroD1 AAV-based gene therapy for functional brain repair after ischemic injury through in vivo astrocyte-to-neuron conversion.分子疗法;28（1），237-234，2020。view PDF
  • Do Monte，FH和Kirouac，GJ。丘脑D2多巴胺能传播的增强：寻求药物衰减的潜在策略。eNeuro，21; 4（6），2017年。
  • 做蒙特，fh*;小型托里比奥*，a;Quiñones-Laracuente，K;Medina-Colón，EM；Quirk，GJ。意外奖励遗漏期间对蔗糖寻求的丘脑调节。Neuron，94（2）：388–400.E4，2017
  • Martínez-Rivera，FJ；Rodríguez-Romaguera，J；Lolet-Torres，我；蒙特,跳频;Quirk GJ，Barreto-Estrada，JL。通过深脑刺激腹侧纹状体刺激药物灭绝的双向调节。Biological Psychiatry, 80 (9):682-690, 2016.
  • 蒙特,跳频;Quirk，GJ;李，b;马萨诸塞州彭佐。随着时间的流逝，取回恐惧记忆。分子精神病学, 21(8):1027-1036, 2016.view PDF
  • 罗萨斯 - 维达尔，le;Rodriguez-Romaguera, J; Do Monte, FH; Andero, R. Targeting the reconsolidation of extinction memories: a novel potential strategy to treat anxiety disorders.分子精神病学, 20(11):1264-5, 2015.view PDF
  • 做蒙特，fh*;Manzano-Nieves*, G; Quiñones-Laracuente, K; Ramos-Medina, L; Quirk, GJ. Revisiting the role of infralimbic cortex in fear extinction with optogenetics.神经科学杂志,35(8):3607-3615, 2015.view PDF(Top 1% most cited paper in the academic field 12 months following publication, according to Web of Science).
  • 蒙特,跳频;Quiñones-Laracuente，K;Quirk GJ。A temporal shift in the circuits mediating retrieval of fear memory.Nature, 519(7544):460-463, 2015.view PDF(Top 1% most cited paper in the academic field 12 months following publication, according to Web of Science)
    • Commentary featured in the journal “Nature Reviews Neuroscience”: Yates, D. (2015). Neural circuits: a nucleus of fear.Nature Reviews Neuroscience16, 121).view PDF
  • Rodriguez-Romaguera, J; Do Monte, FH; Tanimura, Y; Quirk, GJ; Haber, SN. Deep brain stimulation enhancement of fear extinction: evidence for medial orbitofrontal involvement.神经心理药理学，40（7）：1726-1733，2015。view PDF
  • Bravo-Rivera, C; Diehl, MM; Roman-Ortiz, C; Rodriguez-Romaguera, J; Rosas-Vidal, LE; Bravo-Rivera, H; Quiñones-Laracuente, K and Do Monte, FH. Long-range GABAergic neurons in the prefrontal cortex modulate behavior.神经生理学杂志,114：1357-1359，2014。view PDF
  • 罗萨斯 - 维达尔，le;蒙特,跳频;Sotres-bayon，f;Quirk，GJ。海马前额外的bdnf和记忆恐惧灭绝，神经心理药理学,39（9）：2161-2169，2014。view PDF
  • 蒙特,跳频;Rodriguez-Romaguera, J; Rosas-Vidal, LE; Quirk, GJ. Deep brain stimulation of the ventral striatum increases BDNF in the fear extinction circuit.行为神经科学领域。7：102，2013。
  • 蒙特,跳频;Souza，RR；Bitencourt，RM；JA KROON；高桥，RN。将大麻二醇输注到输卵管皮层中有助于通过CB1受体灭绝。行为大脑研究beplay苹果手机能用吗, 250c:23-27, 2013.
  • 做蒙特，fh*;souza，rr*;Wong，TT；Carobrez，美联社。prazosin的全身性或原内皮层输注会损害恐惧记忆的重新整合。行为大脑研究beplay苹果手机能用吗,244：137-141，2013。view PDF
  • Rodriguez-Romaguera，J*;做蒙特，fh*;Quirk GJ。深脑刺激腹纹状体会增强条件恐惧的消失。Proceedings of the National Academy of Science – USA,109(22):8764-8769, 2012.view PDF
  • Padilla-Coreano*, N; Do Monte, FH*; Quirk, GJ. A time-dependent role of midline thalamic nuclei in the retrieval of fear memory.神经药理，62（1）：457-463，2012。view PDF
  • 蒙特,跳频;Kincheski, G; Pavesi, E; Sordi, R; Assreuy, J; Carobrez, AP. Role of beta-adrenergic receptors in the ventromedial prefrontal cortex during contextual fear extinction in rats.学习和记忆的神经生物学,94(3):318-328, 2010.view PDF
  • 加利福尼亚州斯特恩；蒙特,跳频;Gazarini，L；Carobrez，美联社；Bertoglio，LJ。在升高的迷宫重新测试期间调整焦虑反应水平是必需的。神经科学,170:214 – 222, 2010.view PDF
  • 蒙特,跳频;Allensworth, M; Carobrez, AP. Impairment of contextual conditioned fear extinction after microinjection of alpha-1-adrenergic blocker prazosin into the medial prefrontal cortex.行为大脑研究beplay苹果手机能用吗,211:85 – 95, 2010.view PDF
  • 蒙特,跳频;NS坎特拉斯；Fernandes, D; Assreuy, J; Carobrez, AP. New perspectives in beta-adrenergic mediation of innate and learned fear response to predator odor.神经科学杂志,28(49):13296-13302, 2008.view PDF
  • NS坎特拉斯；JA KROON；蒙特,跳频;Pavesi，E；Carobrez，美联社。通过嗅觉系统传感危险：下丘脑背骨上核核的作用。神经科学and Biobehavioral Reviews,32：1228-1235，2008。view PDF
  • 桑托斯小詹;Blanco，MM；蒙特,跳频;Russi, MA; Lanziotti, VM; Leal, LK; Cunha, GM. Sedative and anticonvulsant effects of hydroalcoholic extract ofEquisetum arvense。Fitoterapia，76:508-513, 2005.view PDF
  • 桑托斯小詹;蒙特,跳频;Blanco，MM；Lanziotti，VM；Maia，FD；Leal，LK。长期给药后，老年大鼠认知增强Equisetum arvense l。具有体外证明的抗氧化特性。药理学生物化学和行为，81：593-600，2005。view PDF
  • 桑托斯小詹;Tabosa，a;蒙特,跳频;Blanco，MM；弗里雷，AO；梅洛，勒。电针可防止毛果皮 - 癫痫大鼠的认知缺陷。神经科学Letters,384：234-238，2005。view PDF
  • 蒙特,跳频;桑托斯小詹;Russi, MA; Lanziotti, VM; Leal, LK; Cunha, GM. Antinociceptive and anti-inflammatory properties of the hydroalcoholic extract of stems fromEquisetum arvenseL.在老鼠中。药理研究beplay苹果手机能用吗,49：239 - 243，2004。view PDF
  • 桑托斯小詹;蒙特,跳频;Russi,妈,奥古斯汀,P, Lanziotti,VM. Proconvulsant effects of high doses of venlafaxine in pentylenetetrazole-convulsive rats.巴西医学与生物学研究杂志beplay苹果手机能用吗,35:469 - 472, 2002。view PDF

* denotes equal authorship