传记

Hagan收到来自匹兹堡大学博士学位博士的指导下霍华德·休斯医学研究所的研究员葆拉·格拉博夫斯基博士在他的研究侧重于阐明分子机制负责外显子定义在pre-mRNA选择性剪接。beplay苹果手机能用吗

他最初的博士后训练发生在科林·斯图尔特博士的实验室在美国国家癌症研究所调查的角色印迹基因在哺乳动物发展和癌症。

之后,他加入了卡洛Croce博士的实验室,一个成员的国家科学院医学研究所,博士,Hagan合著的论文高影响定义小分子核糖核酸在癌症的作用。然后他收到额外的培训在波士顿儿童医院/哈佛医学院研究转录后调节微rna生物起源和功能LIN28 / let-7通路是特别感兴趣的。Hagan博士在2012年加入了神经外科学系助理教授。

教育

研究生学校
宾夕法尼亚州匹兹堡大学、匹兹堡(分子、细胞和发育生物学)

感兴趣的领域

beplay苹果手机能用吗研究兴趣

我的研beplay苹果手机能用吗究集中在理解小分子核糖核酸的作用及其转录后的监管机构发育和癌症生物学。我们和其他人已经表明,微rna表达在癌症特异表达和演示了使用小鼠模型为这些非编码直接作用,监管rna癌症启动、进展、转移。此外,我们正在继续我们的研究努力描绘3 '的重要性在基因调控RNA pbeplay苹果手机能用吗olyuridylation,我们最近描述了终端Uridylyl转移酶(TUTase)命名Zcchc11处理Lin28A阻止生物起源的肿瘤抑制let-7 microRNA的家庭。我的癌症研究主要侧重于类型的特点是Lin28A /基因Lin28B过度和let-7损失如成神经管细胞瘤、神经母细胞瘤、非典型畸形杆状的肿瘤,乳腺腺癌。修饰符的努力正在进行屏幕Lin28 / let-7途径可能在癌症和2型糖尿病治疗的潜力。

出版物

最近的出版物(自2004年)

  1. 崔,X。,张,Y。,Yang, J., Sun, X.,哈根,摩根大通德拉·S。,Li, M. (2014) ZIP4 confers resistance to zinc deficiency-induced apoptosis in pancreatic cancer.细胞周期13 (7):1180 - 1196PMCID: PMC4013168
  2. 张,Y。,Yang, J., Cui, X., Chen, Y., Zhu, V.F.,哈根,摩根大通王,H。Yu, X。,Hodges, S.E., Fang, J., Chiao, P.J., Logsdon, C.D., Fisher, W.E., Brunicardi, F.C., Chen, C., Yao, Q., Fernandez-Zapico, M.E., and Li. M. (2013) A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth.EMBO分子医学5:1322 - 1334PMCID: PMC3799489
  3. 信田,G。,Shyh-Chang, N., de Soysa, T.Y., Zhu, H., Seligson, M.T., Shah, S.P., Abo-Sido, N., Yabuuchi, A.,哈根,摩根大通格雷戈里,也是、Asara J.M.,Cantley, L.C., Moss, E.G., and Daley, G.Q. (2013) Fetal deficiency of Lin28 programs life-long aberrations in growth and glucose metabolism.干细胞31:1563 - 1573PMCID: PMC3775935
  4. 陈,L。,张,Y。,Yang, J.,哈根,摩根大通李,m(2013)脊椎动物神经胶质瘤动物模型:理解机制和开发新的疗法。Biochimica et Biophysica Acta-Reviews癌症doi: 10.1016 / j.bbcan.2013.04.003PMCID: PMC372903
  5. 信田,G。,de Soysa, T.Y., Seligson, M.T., Yabuuchi, A., Fujiwara, Y., Huang, P.Y.,哈根,摩根大通格雷戈里,也是,Moss, E.G., and Daley, G.Q. (2013) Lin28a regulates germ cell pool size and fertility.干细胞31:1001 - 1009PMCID: PMC3652309
  6. Abdeen,”栏目,Del Mare, S., Hussain, S., Remaileh, M.A., Salah, Z.,哈根,J。Rawahneh, M。聚氨酯,X.A.,Russell, S., Stein, J.L., Stein, G.S., Lian, J.B., and Aqeilan, R.I. (2013) Conditional inactivation of the mouse WWOX tumor suppressor gene recapitulates the null phenotype.细胞生理学杂志228:1377 - 1382PMID: 23254685
  7. Chang莫莱森,Martinez, N.J., Thornton, J.E.,哈根,摩根大通阮,降低价格,Gregory, R.I. (2012) Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation.自然通讯3:923PMCID: PMC3518406
  8. Piskounova E。,Polytarchou, C., Thornton, J.E., LaPierre, R.J., Pothoulakis, C.,哈根,j . P。Iliopoulos D。,Gregory, R.I. (2011) Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.细胞147:1066 - 1079。PMCID: PMC3227872
  9. 朱,H。,Shyh-Chang, N., Segrè, A.V., Shinoda, G., Shah, S.P., Einhorn, W.S., Takeuchi, A., Engreitz, J.M,哈根,摩根大通卡拉思,M.G.Urbach,。,Thornton, J.E., Triboulet, R., Gregory, R.I., DIAGRAM Consortium, MAGIC Investigators, Altshuler, D., and Daley, G.Q. (2011) The Lin28/let-7 axis regulates glucose metabolism.细胞147:81 - 94。PMCID: PMC3353524
  10. Motiwala T。Zanesi, N。达塔,J。罗伊,S。,Kutay, H., Checovich, A.M., Kaou, M., Zhong, Y., Johnson, A.J., Lucas, D.M., Heerema, N.A.,哈根,J。密苏里州,X。,Jarjoura, D., Byrd, J.C., Croce, C.M., and Jacob. S.T. (2011) AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia.血118:6132 - 6140PMCID: PMC3234669
  11. 文策尔,P.L.,Chong J.L.,Saenz-Robles, M.T., Ferrey, A.,哈根,摩根大通戈麦斯,Y.M.,Rajmohan, R., Sharma, N., Chen, H.Z., Pipas, J.M., Robinson, M.L., and Leone, G. (2011) Cell proliferation in the absence of E2F1-3.发育生物学351:35 - 45。PMCID: PMC3868453
  12. Santanam U。Zanesi, N。Efanov,。,Costinean, S., Palamarchuk, A.,哈根,摩根大通、Volinia年代。、桤木、H。Rassenti, L., Kipps, T., Croce, C.M., and Pekarsky, Y. (2010) Chronic lymphocytic leukemia modeled in mouse by targeted miR-29 expression.美国国家科学院学报》107:12210 - 12215。PMCID: PMC2901490
  13. Liu J.Q.,Joshi, P.S., Wang, C., El-Omrani, H.Y., Xiao, Y., Liu, X.P.,哈根,摩根大通刘,C.G.吴,开出信用证,Bai, X.F. (2010) Targeting activation-induced cytidine deaminase overcome tumor evasion of immunotherapy by CTLs.免疫学杂志184:5435 - 5443。PMCID: PMC2874093
  14. 哈根,摩根大通#Piskounova E。#位于美国罗德岛州,格雷戈里(2009)Lin28新兵TUTase Zcchc11抑制let-7成熟在老鼠胚胎干细胞。《自然结构和分子生物》上16:1021 - 1025。PMCID: PMC2758923
  15. 衰败,公共广播#Fernandez-L,。#,哈根,摩根大通#埃里森,D.W.,Grajkowska, W., Gillespie, Y., Grundy, R., Van Meter, T., Rutka, J.T., Croce, C.M., Kenney, A.M., and Taylor, M.D. (2009) The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors.癌症研究beplay苹果手机能用吗69:3249 - 3255。PMCID: PMC2836891
  16. 哈根,摩根大通,奥尼尔,文学士斯图尔特,中一段科兹洛夫,S.V.,Croce, C.M. (2009) At least ten genes define the imprinted Dlk1-Dio3 cluster on mouse chromosome 12qF1.《公共科学图书馆•综合》4:e4352。PMCID: PMC2632752
  17. Aqeilan,哈根,j . P。德熊,,Rawahneh, M., Salah, Z., Gaudio, E., Siddiqui, H. Volinia, S., Alder, H., Lian, J.B., Stein, G.S., and Croce, C.M. (2009) Target ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis.内分泌学150:1530 - 1535。PMCID: PMC2654736
  18. 雷斯尼克,动向、桤木、H。哈根,摩根大通理查森,D.L.Croce,:,Cohn, D.E. (2009) The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform.妇科肿瘤112:55-59。PMID: 18954897
  19. Chong J.L.,文策尔,P.L.,Saenz-Robles, M.T., Nair, V., Ferrey, A.,哈根,摩根大通戈麦斯,Y.M.沙玛,N。陈,H.Z.Ouseph, M。王,萨达姆政权Trikha, P。,选B。,Mezache, L., Winton, D.J., Sansom, O.J., Chen, D.N., Bremner, R., Cantalupo, P.G., Robinson, M.L., Pipas, J.M., and Leone, G. (2009) E2f1–3 switch from activators in progenitor cells to repressors in differentiating cells.自然462:934 - 1025。PMCID: PMC2806193
  20. Taccioli C。Fabbri E。Visone, R。,Volinia, S., Calin, G.A., Fong, L.Y., Gambari, R., Bottoni, A., Acunzo, M.,哈根,J。人工,装Piovan C。Romano, G。,Croce, C.M. (2009) UCbase & miRfunc: a database of ultraconserved sequences and microRNA function.核酸的研究beplay苹果手机能用吗37:D41-48。PMCID: PMC2686429
  21. Pichiorri F。Suh,轮,Ladetto, M., Kuehl, M., Palumbo,T., Drandi, D., Taccioli, C., Zanesi, N., Alder, H.,哈根,摩根大通芒克,R。,Volinia, S., Boccadoro, M., Garzon, R., Palumbo, A., Aqeilan, R.I., and Croce, C.M. (2008) MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis.美国国家科学院学报》105:12885 - 12890。PMCID: PMC2529070
  22. 饶,Y,李,Y。Jarjoura D。,Ruppert, A.S., Hsu, J.C., and哈根,摩根大通(2008)比较标准化的微阵列数据的技术。统计应用遗传学和分子生物学,7:第二十二条。PMID: 18673291
  23. Aqeilan,Hassan, M.Q., de Bruin, A.,哈根,摩根大通、Volinia年代。,帕伦博,T。侯赛因,S。李,萨达姆政权白肢野牛,T。,Stein, G.S., Lian, J.B., and Croce, C.M. (2008) The WWOX tumor suppressor is essential for post-natal survival and normal bone metabolism.生物化学杂志283:21629 - 21639。PMCID: PMC2490770
  24. 施密德,T。,Jansen, A.P., Baker, A.R., Hegamyer, G.,哈根,摩根大通科尔伯恩,新罕布什尔州(2008)肿瘤抑制Pdcd4目标是在肿瘤的恶化。癌症研究beplay苹果手机能用吗68:1254 - 1260。PMID: 18296647
  25. 哈根,摩根大通、克罗斯、蔡玫(2007)小分子核糖核酸在致癌作用。细胞遗传学和基因组研究beplay苹果手机能用吗118:252 - 259。PMID: 18000378
  26. Kebache, S。灰,J。,Annis, M.G.,哈根,J。胡贝尔,M。,Hassard, J., Stewart, C.L., Whiteway, M., and Nantel, A. (2007) Grb10 and active Raf-1 kinase promote bad-dependent cell survival.生物化学杂志282:21873 - 21883。PMID: 17535812免费的全文
  27. 温斯Aqeilan,哈根,摩根大通、Aqeilan H.A.Petrocca F。方,L.Y.,Croce, C.M. (2007) Inactivation of the Wwox gene accelerates forestomach tumor progression在活的有机体内。癌症研究beplay苹果手机能用吗67:5606 - 5610。PMCID: PMC2621009
  28. Bloomston, M。,Frankel, W.L., Petrocca, F., Volinia, S., Alder, H.,哈根,摩根大通刘,C.G.Bhatt, D。,Taccioli C。,Croce, C.M. (2007) MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis.美国医学协会杂志》上297:1901 - 1908。PMID: 18296647
  29. 温斯Aqeilan,Trapasso, F., Hussain, S., Costinean, S., Pekarsky, Y.,哈根,摩根大通Zanesi, N。Kaou, M。,Stein, G.S., Lian, J.B., and Croce, C.M. (2007) Targeted deletion of WWOX reveals a tumor suppressor function.美国国家科学院学报》104:3949 - 3954。PMCID: PMC1820689
  30. Pekarsky Y。,Santanam U。,Cimmino, A., Palamarchuk, A., Efanov, A., Maximov, V., Volinia, S., Alder, H., Liu, C.G., Rassenti, L., Calin, G.A., Kipps, T.,哈根,摩根大通Croce,蔡玫(2006)Tcl1表达在慢性淋巴细胞白血病是由miR-29和mir - 181。癌症研究beplay苹果手机能用吗66:11590 - 11593。PMID: 17178851免费的全文
  31. Roldo C。,Missiaglia, E., N.,哈根,摩根大通尔孔尼。M。卡佩里,P。、Bersani年代。Calin, G.A.、Volinia年代。刘,C.G.,Scarpa, A., and Croce, C.M. (2006) MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior.临床肿瘤学杂志24:4677 - 4684。PMID: 16966691
  32. Palamarchuk,。Zanesi, N。,Aqeilan,Efanov, A., Maximov, V., Santanam, U.,哈根,摩根大通Croce,:,Pekarsky Y。(2006)Tal1转基因的表达揭示了缺乏B淋巴细胞。癌症研究beplay苹果手机能用吗66:6014 - 6017。PMID: 16778172免费的全文
  33. 风扇、T。哈根,摩根大通科兹洛夫,S.V.,Stewart, C.L., and Muegge, K. (2005)激光冲徊化控制压印的沉默Cdkn1c基因。发展132:635 - 644。PMID: 15647320免费的全文
  34. 哈根,摩根大通斯维尔,L。,Kozlov, S.V., Chiang, Y., and Stewart, C.L. (2004) Intraspecific Mating With CzechII/Ei Mice Rescue Lethality Associated With Loss of Function Mutations of the Imprinted Genes,Igf2r和Cdkn1c。基因组学85:835 - 843。PMID: 16778172