Biography

Dr. Charles S. Cox, Jr., is the George and Cynthia Mitchell Distinguished Chair in Neurosciences and directs the Pediatric Surgical Translational Laboratories and Pediatric Program in Regenerative Medicine at McGovern Medical School at the University of Texas Health Science Center at Houston (UTHealth). He directs the Pediatric Trauma Program at the McGovern Medical School at UTHealth/德克萨斯医疗中心的儿童纪念赫尔曼医院。

考克斯博士是德克萨斯州的本地人，获得了德克萨斯大学奥斯汀分校的本科学位。从得克萨斯大学医学分公司毕业后，他在休斯敦的德克萨斯大学医学院完成了手术住院医师。进一步的研究生奖学金在密歇根大学的小儿手术中完成，NIH T32赞助了Shriner's Burns Institute的心肺支持/循环支持设备/Bio-Hybrid器官的临床和研究奖学金，以及外科手术/创伤学院beplay苹果手机能用吗UTHealth Medical School。他获得了美国外科手术委员会的认证，并获得了儿科手术和手术重症监护方面的资格。

The Pediatric Translational Laboratories and Pediatric Program in Regenerative Medicine is a multi-disciplinary effort that addresses problems that originate with traumatic injury and the consequences of resuscitation and critical care. The Program focuses on progenitor cell based therapy (stem cells) for traumatic brain injury, and related neurological injuries (hypoxic-ischemic encephalopathy, stroke, spinal cord injury), recently completing the first acute, autologous cell therapy treatment Phase I study for traumatic brain injury in children.

The program also develops novel bio-hybrid organs using cell-based and tissue engineering approaches to trauma and injury related problems. These efforts have recently resulted in two IND based cell therapeutic studies, and three patents in the past two years. The program is funded through the National Institutes of Health, Texas Higher Education Coordinating Board, Industry Collaboration, and philanthropic contributions.

Cox博士曾在美国国立卫生研究院，美国心脏协会，退伍军人事务奖，国防部，国会导演的医学研究计划以及加拿大，新加坡和新加坡的国家研究计划的科学研究部分/审查小组中beplay苹果手机能用吗捷克共和国。他是100多个科学出版物，20本书章节的作者，并且是新闻界题为《神经损伤的祖细胞疗法》中文本的编辑。

教育

BA
English Plan II Honors - University of Texas at Austin, Austin, TX, 1984
MD
Doctor of Medicine - University of Texas Medical Branch, Galveston, TX, 1989
Internship
General Surgery - University of Texas Health Science Center at Houston, 1990
Residency
General Surgery - University of Texas Health Science Center at Houston, 1994
beplay苹果手机能用吗研究奖学金
创伤与伯恩斯 - 德克萨斯大学医学分公司，德克萨斯州加尔维斯顿，德克萨斯州，伯恩斯伯恩斯研究所，1992年
Fellowship
Pediatric Surgery - University of Michigan, Ann Arbor, MI, 1996
Fellowship
Surgical Critical Care - University of Texas Medical School at Houston, 1997

Areas of Interest

Clinical Interests

Colorectal Diseases, Gastroesophageal Reflux Disease (GERD), Laparoscopic Hernia, Minimally Invasive Surgery, Pediatric Surgery, Trauma Surgery

Research Interests

小儿创伤性脑损伤，自体间充质干细胞治疗儿童脊髓损伤的安全性，自体人体血液的安全性作为儿童创伤性脑损伤的治疗

beplay苹果手机能用吗研究信息

  • Pediatric Traumatic Brain Injury
    脑外伤（TBI）每年在美国影响近150万患者，其耗资近600亿美元与之相关。TBI导致长期的身体和认知缺陷。TBI是一种中枢神经系统（CNS）损伤，破坏了免疫系统与CNS之间的正常相互作用。中枢神经系统损伤会导致炎症介质的产生或神经免疫相互作用电路中稳态信号的破坏。免疫反应受远处的器官（例如脾脏和胸腺）的控制，当与祖细胞疗法结合使用时，它们是“生物反应器”。“生物反应器”的一个潜在靶标是小胶质细胞，这是中枢神经系统的驻留免疫反应细胞。受伤后，小胶质细胞（巨噬细胞）分化为两种不同的表型。损伤后的早期阶段由被认为是促炎的M1小胶质细胞支配。他们可能释放促炎性细胞因子，例如IL-1，IL-6和TNFα。其他小胶质细胞（M2）是抗炎的。 It releases cytokines such as IL-4 and IL-10. The ratio of M1 vs M2 is potentially a critical factory in a prolonged inflammatory state. We are currently investigating the signaling mechanisms that govern this ratio and the subsequent consequences of the changes in the ratio of M1:M2 when combined with progenitor cell therapy. In addition, we are also examining the role of tissue (Electrospun) scaffolds as carriers for cells intended to treat TBI. Tissue scaffolds provide mechanical, geometric and chemical indicators that promote and modulate cell growth. Electrospinning is a relatively simple method of producing tissue scaffolds with geometries similar to those found in the extracellular matrix (ECM) of living tissue. The process of electrospinning involves the use of an electric field to extrude thin fibers that accumulate to create the scaffold. Electrospun scaffolds have been applied to many different areas of the body including blood vessels, bone, and nerve grafts, and can be used with either natural or synthetic biomaterials. We are attempting to use electrospun scaffolds as carriers for cells intended to treat traumatic brain injury (TBI). This requires studying the fabrication parameters that influences cell growth, and the potential for neuroprotection and neurogeneration following TBI.
  • Safety of Autologous Mesenchymal Stem Cell Therapy for Spinal Cord Injury in Children
    这是FDA批准的试点研究,由Children’s Memorial Hermann Hospital and sponsored in part by TIRR, to determine if bone marrow harvest and transplantation are safe in children with SCI. Ten children, ages 0-15 years of age who have suffered a SCI within 6 months to 4 years of study enrollment, will undergo bone marrow aspiration. Following cell processing, the children will then receive an Intravenous infusion of their cells. They will return at 30 days and 6 months post-procedure for follow-up to assess late functional outcome using pre-transplantation spinal cord function as the control.
  • Safety of Autologous Human Cord Blood as a Treatment for Traumatic Brain Injury in Children
    这是FDA批准的试点研究,由Children’s Memorial Hermann Hospital and sponsored in part by Cord Blood Registry (CBR), to determine if autologous hUCB transplantation for TBI is logistically feasible and safe. Ten children, ages 18 months -17 years who have suffered a severe to moderate TBI 6 months to 18 months prior and who have their own cord blood banked at CBR, will receive an intravenous infusion of their cord blood derived cells. Follow-up will occur at 6 months, 1 year and 2 years post-procedure to assess improvement using pre and post-TBI neuropsychological and imaging outcomes measures.

Publications

Publication Information

  • Walker PA, Bedi SS, Shah SK, Jimenez F, Xue H, Hamilton JA, Smith P, Thomas CP, Mays RW, Pati S, Cox CS. Intravenous multipotent adult progenitor cell therapy for traumatic brain injury: Modulation of microglia/macrophages. J Neuroinflammation 9:228-240, 2012. PMID: 23020860
  • Chu J，Pham NT，Y酸NT，Kislitsyna K，Day MC，Letourneau P，Kots A，Stewart RH，Laine GA，Cox CS，Cox CS，Uray K.肌球蛋白轻链磷酸化对P 21激活激酶的双重调节，可激活激酶调节型肌肉平滑的肌肉平滑肌肉缩写效率。J Biol Chem 288：1200-1213，2013。PMID：23161543
  • Treble A, Hasan K, Ittikhar A, Cox CS, Stuebing K, Swank P, Ewing-Cobbs L. Working memory and corpus callosum microstructural integrity following pediatric traumatic brain injury: A diffusion tensor tractography study. J Neurotrauma 30:1609-1619, 2013. PMID: 23627735.
  • Olsen AB, Hetz RA, Xue H, Aroom KR, Bhattarai D, Johnson E, Bedi S, Cox CS, Uray K. Effects of traumatic brain injury on intestinal contractility. Neurogastroenterology Motil 25:593-597, 2013. PMID: 23551971
  • Bedi SS, Smith P, Hetz R, Caplan H, Cox CS. Immunomagnetic enrichment and flow cytometric characterization of mouse microglia. J Neurosci Methods 219:176-182, 2013. PMID: 23928152
  • Bedi党卫军,Hetz R,托马斯·C,奥尔森,威廉姆斯年代,Smith P, Xue H, Aroom K, Uray K, Hamilton T, Mays RW, Cox CS. Intravenous multipotent adult progenitor cell therapy improves spatial learning after traumatic brain injury. Stem Cells Translational Med 2:953-960, 2013. PMID: 24191266
  • Bedi SS, Walker PA, Shah SK, Jimenez F, Thomas CP, Hetz RA, Xue H, Pati S, Dash PK, Cox CS. Autologous bone marrow mononuclear cell therapy attenuates activated microglia/macrophage response and improves spatial learning after traumatic brain injury. JTrauma Acute Care Surg 75:410-416, 2013. PMID: 23928737