The Cancer Prevention and Research Institute of Texas (CPRIT) awarded over $6 million to researchers with UTHealth Houston to aid in cancer prevention research. These awards will expand liver cancer prevention to persons experiencing homelessness, facilitate communication about the HPV vaccine, and find therapeutics that can help destroy gastrointestinal cancer cells.

有无家可归经验的人中的肝癌预防：南德克萨斯州的低收入住房扩张

A nearly $2 million grant has been awarded to Vanessa Schick, PhD, associate professor in the Department of Management, Policy and Community Health at UTHealth School of Public Health in Houston; and Jack Tsai, PhD, professor and dean of UTHealth School of Public Health in San Antonio, to lead an expansion of the program called GRASSROOTS HEALTH.

这是休斯顿和圣安东尼奥的一项创新计划，旨在消除有无家可归风险的个体中乙型肝炎和C的教育，测试和治疗障碍。基层健康为休斯顿有无家可归风险的数百个人提供了服务，而新希望住房和无家可归的休斯顿的医疗保健的现有合作伙伴。这项赠款将使研究人员能够将该计划扩展到退伍军beplay苹果手机能用吗人和南德克萨斯州。

“Offering hepatitis B and C services are important to prevent liver cancer and this community health project will work with communities with histories of unstable housing to bring these services directly to their door,” Tsai said.

基于AI的对话代理，用于促进有关儿童和青少年HPV疫苗接种的教育和沟通

Cui Tao, PhD, professor at UTHealth Houston School of Biomedical Informatics, has been awarded $1.3 million to develop an interactive conversational agent to enhance HPV vaccine awareness. Unlike the familiar voice agents like Apple Siri or Amazon Alexa that implement a simple adjacency pairing interaction and requires user initiation, researchers will use a dialogue system that enriches a speech-enabled software agent to have prolonged, consistent, and lightweight counseling with a health consumer where the agent drives the conversation about the HPV vaccine.

“Human papillomavirus (HPV) infections cause about 34,000 cases of cancers every year in the U.S.,” Tao said. “A previous study reported that if the population were to have 70% coverage of the HPV vaccine, at least 4 million deaths worldwide could be prevented in the next decade. For the HPV vaccine to be effective, patients need to complete the two- to three-dose series. Currently, the completion rates for the HPV vaccine for adolescents in the United States population is 48.6%, short of the 80% uptake goal.”

对话系统将为代理提供有关HPV疫苗和相关主题的领域知识，以及自主对话互动的智能。beplay苹果手机能用吗研究人员将试行与父母和年轻人测试对话剂，以衡量其有效性和可行性。

Simultaneous Targeting of LGR4/5/6 for the Treatment of Gastrointestinal Cancer

beplay苹果手机能用吗休斯顿乌西顿麦戈文医学院的研究人员希望使用其100万美元的赠款来创造候选药物，这些候选者在杀死胃肠道癌细胞方面高度有效且有效。

“胃肠道癌，包括结直肠癌，胃癌和肝癌，是德克萨斯州和美国其他地区与癌症相关死亡的主要原因，”该项目的首席研究员兼教授兼教授兼总监Qingyun Liu博士说。布朗基金会分子医学研究所预防麦戈文医学院人beplay苹果手机能用吗类疾病的转化癌研究。“特别是，在得克萨斯州，肝癌越来越普遍，几乎没有可用的治疗选择。我们已经鉴定出一种类似于抗体的蛋白质，该蛋白质可以特异性地与胃肠道癌细胞上的一组受体结合并阻止其功能。”

Researchers hope to attach a cytotoxic payload to the peptibody that will generate a peptibody-drug conjugate (PDC) that can deliver the payload to and kill cancer cells with high levels of the receptors. “This strategy is similar to that of antibody-drug conjugate (ADC) which has been successfully used for cancer treatment. Success of this project may lead to the development of novel therapeutics for a broad category of cancers,” Liu said.

增强肽受体放射性核素治疗的作用

麦戈文医学院分子医学研究所副教授Ali Azhdarinia博士获得了100万美元的赠款，以开发一种新方法，以改善已FDA批准的神经内分泌肿瘤的治疗效果。

“A large proportion of these patients are already receiving an approved therapy that delivers cell-killing radiation to tumors. The effects of that treatment can be significant, but patients will eventually relapse,” said Azhdarinia.

Azhdarinia与德克萨斯大学医学博士Anderson癌症中心的联合主要研究员Daniel Halperin合作，已开发出一种新方法，使肿瘤对放射疗法更加敏感，而不会损害健康的器官。

“如果成功的话，我们的研究将产生一种新型beplay苹果手机能用吗的以肿瘤为目标的治疗方法，将与辐射结合使用，以最大程度地发挥抗肿瘤作用并减少复发的可能性。”

Quantitative NIRFLI Scanning of Lymphatic Dysfunction in Head and Neck Cancer Patients for Early Diagnosis of Cancer-Acquired Lymphedema

John Rasmussen, PhD, assistant professor at the Institute for Molecular Medicine at McGovern Medical School, will use a nearly $1 million grant to integrate and validate the use of computer vision technology into the near-infrared fluorescence lymphatic imaging (NIRFLI) system to scan and quantify areas of lymphatic dysfunction in patients with head and neck cancers to guide and monitor response to physiotherapy.

“头颈癌是全球第七种最普遍的癌症，尽管使用与其发病率相关的烟草产品的使用下降，但人类乳头瘤病毒（HPV）的流行可能是全球这些癌症以及在美国，在美国，在美国，可能是这些癌症的流行。拉斯穆森说。

在先前的CPRIT资助下，研究人员在头颈癌患者的纵向研beplay苹果手机能用吗究中使用NIRFLI，在几个月和几年内表现出持续性和进行性淋巴功能障碍。在这项新赠款中，研究人员将在当前的淋巴beplay苹果手机能用吗成像系统中添加3D成像功能，以促进临床环境中头部和颈部皮肤回流的定量。在将3D计算机视觉技术纳入系统之后，他们希望进行一项小型试验临床试验，以评估癌症治疗后12个月的淋巴处理（以及随后淋巴水肿的后续发作）对治疗的反应。

“如果成功,我们何pe to provide evidence that our imaging technique can detect lymphedema prior to clinical onset and that early treatment prior to onset may prevent the development and/or progression of lymphedema all together,” Rasmussen said.

提供了CPRIT赠款，以扩大获得临床试验的机会，孵化创新的癌症研究，支持该州新兴的生物技术行业，为服务不足的德克萨斯人提供所需的癌症筛查，并招募出色的癌症研究人员到德克萨斯州beplay苹果手机能用吗。

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