瑞安·洛根（Ryan Logan）的队友将他称为“子弹”以闪电般的Quick Jukes和开拓性的速度 - 11岁的足球场上的运动能力是无与伦比的。他的机智比脚更快地拉开了，他还在有才华和才华横溢的课程中表现出色，并在整个学校结交了朋友。唯一使他陷入的事情是神秘的头痛和视觉障碍。
In February 2013, Ryan’s doctors made a startling discovery: A brain scan revealed a grade 4 arteriovenous malformation (AVM), which is a massive tangle of abnormal blood vessels connecting arteries and veins in his brain. His snarled blood vessels were at risk of rupturing, which can cause life-threatening bleeding in the brain.
beplay苹果手机能用吗研究人员估计大脑AVM不到1％的人口。通常没有症状，其中一半的人作为第一个迹象而遭受严重的出血。
Although doctors caught Ryan’s brain AVM before further complications struck, they warned that surgical removal would be too dangerous. “Learning our child has a ticking time bomb in his body was devastating,” says Ryan’s father, Mark. “It was an impossible situation. Removing it could debilitate him, but leaving it alone could cause his death.”
为了帮助确保其他家庭永远不必忍受这种焦虑，Logans决定建立动静脉畸形研究基金会。beplay苹果手机能用吗马克说：“我们必须帮助找到对脑AVM的更安全的治疗方法。”
提高赌注
Ryan’s brain AVM raised the stakes in September 2014 when the AVM suffered a spontaneous hemorrhage that landed him in the hospital for three days. Because one rupture greatly increases the odds it will happen again, doctors believed surgery was his best shot to avoid a fatal brain bleed.
After consulting renowned specialists across the nation, the Logans met UTHealth neurosurgeon David I. Sandberg, MD. Sandberg’s exceptional care earned the family’s trust, and he devised a plan to remove Ryan’s AVM with neurosurgeons P. Roc Chen, MD, and Arthur L. Day, MD. The surgery would take place in three procedures over six weeks in July 2015.
在第一次阻塞动脉并减少血液流入Ryan的AVM的过程中，AVM开始关闭自身，引发致命的出血。陈有几分钟来挽救生命。
瑞安（Ryan）的母亲谢里（Sherri）说：“瑞安（Ryan）今天不会在这里。”“博士陈的专业知识是介入放射科医生和神经外科医师，使他能够立即停止出血并减轻瑞安头骨中的压力。”
Over the next six weeks, Ryan remained in a medically induced coma while Chen and Day worked to remove about 70% of the brain AVM.
Research to find a safer treatment
当Logans听说Chen有兴趣开始对AVMS的研究时，他们采取了行动来提高支持。beplay苹果手机能用吗尽管脑AVM不是遗传性的，但Chen的团队认为他们发现了一种基因突变，可以解锁无创疗法。
“Our family mission is to continue to fight AVM and be there for other families along the way,” says Mark. “We established the AVM Research Foundation to help Dr. Chen discover a safer, noninvasive way to remove AVMs.” Since 2017, the AVM Research Foundation has helped raise $350,000 to support Chen’s research by hosting an annual crawfish boil, an annual golf tournament, and other events.
Setting the pace
经过将近四年的身体，职业和言语疗法，瑞安的家人感到有一件事阻止瑞安恢复子弹速度，这是他的AVM破裂后开始的癫痫发作活动。几乎不断的癫痫发作活动干扰了他的认知和身体和精神上改善的能力。
In February 2019, leading UTHealth epilepsy surgeon Nitin Tandon, MD, conducted a 16-hour procedure on Ryan—comprising of a functional hemispherectomy to disconnect the right side of Ryan’s brain where seizure activity had taken root, removal of the remaining brain AVM, and a cranial vault reconstruction.
“Ryan’s spirit and love of life are what strike me most,” says Tandon. “As soon as he awoke from surgery, his wit returned, and you could sense a change.”
瑞安（Ryan）在17岁那年就进入了高中的高中 - 没有癫痫发作和迫在眉睫的大脑AVM威胁。尽管短期记忆力丧失和身体障碍，他仍在努力重新获得独立生活的技能。马克说：“他的动作很快，以至于我们一直忘记他只是进行了大脑部手术。”“天空是他的极限。”
With years of recovery behind him, Ryan looks forward to his senior year of high school and spreading his wings after graduation. “The care Ryan received at UTHealth was unbelievable,” says Sherri. “There are so many others living with inoperable brain AVMs, but thanks to research like Dr. Chen’s, those families will one day be able to rest easy.”
TEXAS INSTITUTE FOR RESTORATIVE NEUROTECHNOLOGIES
The Texas Institute for Restorative Neurotechnologies aims to establish UTHealth as the nation’s leading center for epilepsy care, research, and education. In February 2019, it became a reality behind the expertise of Tandon and two recent faculty recruits: Samden Lhatoo, MD, and GQ Zhang, PhD.
Tandon is at the forefront of leading-edge brain surgery that eliminates seizures with laser precision after pinpointing the source of the epilepsy with fine electrode probes. “Fueled by our groundbreaking work in epilepsy, the Texas Institute for Restorative Neurotechnologies will advance the clinical neurosciences of tomorrow,” he explains. “We will extend our work to explore innovative therapies for functional neurosurgical disorders, brain-machine interfaces, neuroinformatics, Big Data, and precision neurological therapies.”
Lhatoo specializes in the medical and surgical treatment of complex, difficult-to-treat epilepsy. He has a particular expertise in understanding the mechanisms of fatalities in patients with epilepsy and helping prevent them. “We have the right individuals in the right place to investigate critical problems such as sudden unexpected death in epilepsy, to improve the lives of patients in Texas and beyond,” he says.
张通过开发创新的工具，使专家能够收集和评估大量数据，从而将数据分析的力量带入了癫痫的诊断和管理。他说：“信息就是力量。”“通过利用我们的数据，除癫痫病外，我们将能够扩大对其他神经系统疾病的影响。”
As co-directors of the Texas Institute for Restorative Neurotechnologies, Tandon, Lhatoo, and Zhang are positioning UTHealth to advance not just the field of epilepsy, but the entire field of brain and behavioral health.
