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生物化学和细胞生物学

The Biochemistry and Cell Biology (BCB) Graduate Program is a rigorous, interdisciplinary program that focuses on understanding fundamental biological, biochemical and molecular underpinnings of normal cellular and organ function, and how these mechanisms affect normal and abnormal (disease) biological function.

BCB COURSE REQUIREMENTS

Year 1

GS21 1017 Foundations in Biomedical Research (7 credits)

GS21 1051伦理维度生物医学科学(1个学分)

GS13 1024细胞信号的分子基础(3个学分)

Year 2

GS03 1023生物化学和细胞生物学的当前方法(3个学分)

科学写作(1个学分)

GS12 1011 BCB研讨会系列(1个学分)

Weekly seminars*

3年级以上

候选人资格(可以在课程描述下找到详细信息)

GS12 1011 BCB研讨会系列(1个学分)

Weekly seminars*

BCB选修课(两门课程)

防御


*所有学生都必须参加BCB研讨会系列GS12 1011,只有固定后的学生才能出席。

* All students should attend at least one department seminar per week

课程描述

  • BCB Seminar Series
    课程细节

    GS12 1011 (1 credits)
    春天和秋季

    Poulsen,凯尔。一个小时。每年春季和秋季。分级系统:通过/失败。允许审核。先决条件:无。

    该课程是一个论坛,在该论坛上,学生,博士后研究员和偶尔的教职员工介绍他们正在进行的研究,以促进讨论,​​学习和科学互动。beplay苹果手机能用吗讨论的研究领域包括beplay苹果手机能用吗基本和转化细胞生物学和生物化学,涉及癌症,肌肉和肾脏生理学的主题,神经科学,蛋白质结构/功能以及心血管和昼夜节律生理学。所有学生将有望参加讲座并参加讨论。期望学生有望提出一个45分钟的研讨会,描述他们的论文研究beplay苹果手机能用吗

  • 当前的生物化学和细胞生物学方法
    课程细节

    GS03 1023 (3 credits)
    Fall

    Putkey, 约翰。三个学期。每年秋天。评分系统:字母等级。先决条件:GS21 1017:生物医学研究的基础或本科生物化学的2个学期。beplay苹果手机能用吗

    本课程的目的是指导学生采用与结构和分子生物学相关的最前沿方法论。班级会 consists在星期一,星期三和星期五举行的43个1小时的讲座中。基于其相关技术的专业知识,从多个GSB的研究生课程中选择个别讲师。演讲将为从QRT-PCR到代谢组分析到基本重组蛋白表达和分析的技术曲目的原理,适当的应用和局限性提供声音基础。该课程旨在通过核心课程涵盖的技术协同作用。

  • 高级研究研讨会的设计和交付beplay苹果手机能用吗
    课程细节

    GS04 1751 (1 credits)
    Fall

    布雷顿,吉斯兰。一个学期。每年秋天。分级系统:通过或失败。先决条件:无

    This course has two major objectives. The first is to familiarize students with current research in regulatory biology with particular emphasis on molecular mechanisms of cell regulation and signaling. The second goal is to teach students how to give outstanding research seminars. Weekly 90-minute meetings involve alternate faculty and student presentations on current problems in regulatory biology. Faculty presentations introduce each topic and provide a broad and critical overview of approaches used to tackle research problems. Student presentations cover recent articles from leading journals on the same topic. Students are instructed in the preparation of slides/overheads, seminar organization and techniques of oral presentation and are given detailed feedback by faculty and fellow students following their presentations. Three to four topics are covered each year and the topics discussed vary annually. Students can, and often do, register for the course multiple times during their graduate careers.

  • Molecular Basis of Cell Signaling
    课程细节

    GS13 1024 (4 credits)
    春天

    杜,广播。四个学期。春季,每年。评分系统:字母等级。先决条件:生物化学和细胞生物学背景;教练的同意。

    本课程提供了对细胞信号的分子基础的详细探索,重点是最新的发展,结构功能和定量。该课程将包括对第二信使系统(GPCR,G蛋白,CAMP,IP3和脂质)的调节,离子通道,生长因子调节的酪氨酸激酶,小G蛋白(RAS,GEFS,GEFS,GAPS,GAPS,GAPS),激酶/磷酸酶途径,激酶途径,磷酸酶途径,激酶/磷酸酶途径,激酶途径,激酶/磷酸盐酶途径,激酶/磷酸酶途径,激酶/磷酸酶。类固醇激素/转录以及这些系统的建模。

  • Scientific Writing for Grant Proposals
    课程细节

    GS03 1111 (1 credits)
    Summer Session

    Cheng, Xiaodong; Gorfe, Alex. One semester hour. Summer annually. Grading System: Letter Grade. Prerequisite: GSBS Core Course.

    这个迷你课程的目标是学习如何编写有效的赠款建议。关于NIH赠款的组成部分,将进行正式的讲座,然后写研讨会。该课程还将包括一个模拟研究部分,并对书面建议的同行评审。

    本课程满足GSB的写作要求。

  • 分子医学主题
    课程细节

    GS21 1611(1个学分)
    所有学期

    Milewicz, Dianna. One semester hour. Fall, Spring, and Summer, annually. Grading System: Pass or Fail. Prerequisite: MD/PhD students only; consent of instructor (Pass/Fail only)

    研讨会将使用选定的主题分子medicine as a vehicle to introduce students to basic ideas of biomedical research, to the skills involved in evaluating the research literature and presenting data, and to the interplay between the research laboratory and the problems of clinical medicine. Students will be expected to conduct literature reviews, make oral presentations of research papers, and participate in the discussions of each topic. The course is offered in the Fall, Spring, and Summer semester, and MD/PhD students are required to register for the course throughout their tenure in the Program except during the third and fourth years of Medical School when schedules for clinical rotations conflict with the weekly seminar.

候选考试描述

Approved by the BCB Steering Committee 01/05/21; updated 1/07/21

BCB学生必须参加研究建议基于学生预期论文项目的主题候选考试。beplay苹果手机能用吗没有预期的重要初步数据,也不应成为推迟合格考试的原因。

1.候选人考试时机
The BCB Program will follow GSBS guidelines with respect to timing of the candidacy exam. Ph.D. students who matriculated in a Fall semester must submit the candidacy exam petition to the GSBS Academic Standards Committee by August 31 of the first term of the third year. The exam must be completed by the end of the first term of the student’s third year. M.D./ Ph.D. students must petition by the end of the Fall Term of GS2 and complete their exam by the end of Spring term of GS2. The Program will honor extensions granted by GSBS. All students must take their candidacy exam within 8 weeks of the approval of their Specific Aims page by the Academic Standards Committee (ASC). The final exam proposal is due to the student’s Candidacy Exam Committee and to GSBS for Turnitin analysis three weeks prior to the exam date. Students should consult the GSBS website for form submission requirements and plan accordingly. Students are encouraged to begin making arrangements for the exam 4-5 months in advance, as described in the following sections.

2.成立候选考试委员会
该计划主任将任命计划考试委员会(PEC)。这应包括大约10个BCB计划教师,代表该计划的各种利益。委员会成员应在BCB学生候选人考试中提供服务。BCB学生必须从该阵容(包括主席)中选择其5名考试委员会成员中的4名。第五会员必须来自BCB计划之外。学生候选考试委员会最多两个成员也可能是学生咨询委员会的成员。学生考试委员会的一名成员必须具有与该提案主题的专业知识明显不同;该成员可以是计划外的人,也可以是PEC成员之一。

The PEC Chair serves for the academic year and must chair all BCB student exams for that academic year unless a conflict of interest or scheduling exists, in which case an Alternate Chair will serve. The committee is responsible for ensuring consistency and high standards of both the written and oral portions of the candidacy exam. Students are strongly encouraged to consult with the Program Director and/ or the PEC Chairperson while selecting committee members, prior to requesting that individual faculty serve on the exam committee in order to ensure adequate diversity and expertise. If the student and mentor feel strongly that particular critical expertise is not represented by the faculty listed on the PEC roster to permit a thorough and fair examination, the student should contact the Program Director to determine whether ad hoc PEC members should be appointed.

BCB计划考试委员会9/1/2021-8/31/2022

Kristin Eckel-Mahan, Chair
Askar Akimzhanov,备用椅子
Shane Cunha,常规成员
Vihang Narkar,常规成员
凯瑟琳·丹尼库尔特(Catherine Denicourt),常规会员
丹妮尔·吴(Danielle Wu),常规成员
Mikhail Kolonin,常规成员
Zheng Chen, Regular Member
广维杜,常规会员
Scott Evans, Regular Member
江里杨,常规会员
liuqing Yang,常规成员

3.候选考试格式
该考试包括一份书面6页的“内部”研究建议,与学生的计划论文项目和委员会的现场口试有关。beplay苹果手机能用吗口腔检查将由学生简要介绍该提案,然后由委员会进行的问题/答案会议。在口试结束时,委员会将评估学生的表现并确定结果,当时将与学生传达。

4.准备书面建议
a.提案概念。作为编写研究建议的第一步,学生必须编写特定的目标页面。beplay苹果手机能用吗研究建议的主题将与学生的预期论文项beplay苹果手机能用吗目有关。该目标必须得到学生咨询委员会的审查和批准,然后再转交GSBS学术标准委员会进行最终批准。理想情况下,应在咨询委员会会议上提出和讨论。然后,学生根据批准的旨在在口试中辩护的目标准备一项完整的研究建议。beplay苹果手机能用吗

b。编写建议。BCB候选考试建议应描述一个新的假设,该假设是由文献或学生自己的初步数据所支持的严格的先前研究支持的。beplay苹果手机能用吗学生应建议使用合适的实验方法在学生开发的特定目标中检验这一新假设。对于开发特定目的或提案的任何方面,初步数据不是必需的。学生无需提出他/她计划实际进行的目标,但他们可能会这样做。该提案将遵循NIH个别个人奖学金申请的格式。

完整的建议是至少在口试日期前三周通过电子邮件归功于候选考试委员会。The committee will review the proposal and determine whether it is suitable for an oral examination. If the proposal is not of sufficient depth or quality, the committee may ask the student to rewrite a portion or the entirety (rarely) of the proposal.

咨询和学术行为。该提案的所有部分必须由学生独立写。尽管学生提案的具体目标可能类似于与顾问协商出于其他目的而开发的目标,但文本必须完全由学生的写作而不是其他人组成。将要求学生的论文顾问验证该提案是与导师现有的书面建议不同的原始贡献。该学生可以从其他学生,包括同学,一般教师和论文顾问在内的其他人的书面考试提案中寻求反馈。除学生自己的论文顾问外,当前BCB计划审查委员会(包括学生委员会中包括学生委员会的人)不得提供有关书面建议的反馈或编辑。

这是允许为了使学生提交候选人考试,以前以自己的名义提交的一些个人奖学金提案,以供NIH或其他机构进行资金考虑。即使导师提供了输入,也可以利用此类建议或其部分。强烈鼓励学生审查此类以前的奖学金建议,以确定多元化科学小组对考试的适用性。

C。提案格式。For details on formatting requirements, please consult the PHS SF424(R&R) Fellowship Instructions on the NIH website. Generally, proposals are single-spaced with minimum 0.5” margins and 11 pt font; several fonts are allowable. Arial is suggested.

-封面:标题,学生名称,教师顾问的名称,考试日期

-抽象的(最大350个字):提供项目,假设,意义和方法的概述

- 特定目标(1页):简洁,现实地陈述研究旨在完成和/或要检验的假设。beplay苹果手机能用吗

- beplay苹果手机能用吗研究策略(6 pages)
意义:Briefly sketch the background to the proposal, critically evaluate existing knowledge, and specifically identify gaps which the research is intended to fill. State concisely the importance of the research by relating the Specific Aims to long-term objectives. (suggested 1-2 pages of the 6 allowed for Research Strategy).

方法:简要总结实验设计以及用于完成本研究的具体目标的程序。beplay苹果手机能用吗包括描述要获得的数据类型以及如何分析它们以实现特定目标,以及(可选的)初步结果,这些结果直接基于提案的基本原理和特定目的。另外,学生可以引用学生或其他人的出版作品。

引用的参考文献
(not counted toward page limit)

5.准备口试
a. Oral examination format. The oral examination is comprised of an opening presentation of the research proposal by the student (20-25 min). Visual aids are permitted, and the presentation will not be interrupted. The committee will then conduct an oral examination (up to 3 hours) covering the proposal, directly related areas, general and background information, breadth questions, and other questions as the committee deems appropriate. No questions will be provided to the student in advance of the exam.

-Assessing Depth.在口试期间,委员会将研究学生对研究建议的智力基础的理解,相关背景,技术方法的细节和实验策略,对结果的解释,潜在的陷阱和替代方法。beplay苹果手机能用吗The Examination Committee will carefully assess the student’s responses to determine whether the student has adequate depth of understanding to carry forward as a post-candidacy student and, in part, as confirmation that the student made original and substantial contributions to the overall conception of the proposal.

-Assessing Breadth.在收到书面考试部的一部分t before the oral exam, the Examination Committee will confer in order to devise a cohesive and fair plan to evaluate the breadth of the student’s knowledge. Breadth questions and topics will be related to the proposal but will also effectively examine the student’s breadth of knowledge. The Examination Committee will choose the most effective questions (usually ~2-3 per committee member) to be used during the examination. These questions are not provided to the student in advance. The Examination Committee Chair will be responsible for ensuring that breadth is assessed in a fair manner among all student exams that year.

b。Preparation for the oral examination。鼓励学生审查相关文献,并能够向聪明的(不一定是专家)的科学家解释并捍卫他们的拟议研究。还鼓励学生从课程中审查内容,因为将向委员会了解学生的先前学术工作。演示文稿幻灯片和演示应进行排练,以进行时机和清晰度。强烈鼓励练习实时问题。成功的博士学位candidate will know the difference between “It is not known” and “I do not know” and will be ready to discuss what is and is not known in the relevant literature or the student’s own work, as well as to propose new or alternative experiments in real time to address gaps in scientific knowledge.

咨询和学术行为。The student may seek feedback on the visual aids and presentation for the oral examination from others, including fellow students, postdocs and at-large faculty. The student is encouraged to schedule mock (also termed “practice”) exams.The thesis mentor and faculty currently serving on the Program Examining Committee are not permitted to attend or participate in mock/practice exams or Q/A sessions that are for the specific purpose of practicing for the candidacy examination.允许在科学讨论或实验室会议期间进行常规Q/A,无论讨论是否与候选考试建议中还包括的目的或实验有关。作为正常科学话语和培训的一部分,学生可能总是会询问导师或任何其他教师的问题,以了解其背景,技术,实验设计或对数据的解释。不期望学生改变其科学互动的性质或内容,而是要求学生将他们的导师和PEC教师排除在模拟考试之外。

6.Performance Assessment
考试结束后,委员会将在没有在场的学生的情况下私​​下授予。书面建议,深度和广度组件的性能分别为无条件通过,有条件的通过,重新检查或失败。所有零件都必须通过,但是每个零件都可以单独补充。考试结果和补救机制(如有必要)将由考试委员会确定,并由考试委员会主席以书面形式传达给学生,计划主任和GSB。考试委员会还将向学术标准委员会提出建议,以了解是否应允许学生绕过硕士学位。程度。GSB Rubric也将由椅子提交给GSB。在重新检查或失败的结果中,鼓励学生与考试主席和委员会成员会面,讨论改进的建议。在失败的结果中,学生的顾问,咨询委员会和GSBS院长学术事务将确定是否应授予学生完成终端硕士学位的机会。程度。

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