The University of Texas Health Science Center at Houston
麦戈文医学院
生物化学和分子生物学系

慢性肺部疾病是美国第三大死亡原因，目前尚无针对这些疾病的有效疗法。慢性肺疾病的例子包括慢性阻塞性肺疾病（COPD），肺纤维化，哮喘和肺动脉高压。我的实验室专注于揭示新的信号通路，这些途径控制着这些疾病中过度重塑的重塑，目的是开发新的治疗选择。我实验室中的研究生将使用来自慢性肺部疾病患者的组织和细胞，以及复杂的转基因小鼠，以对该地区进行基本和转化研究。beplay苹果手机能用吗

PubMed

Google Scholar

Blackburn Lab

Publications

• 通过表达局灶性粘附蛋白来增强细胞外腺苷水平恢复急性肺损伤中的屏障功能
• MicroRNA-98 reduces nerve growth factor expression in nicotine-induced airway remodeling
• Downregulation of CFIm25 amplifies dermal fibrosis through alternative polyadenylation
• Transforming growth factor β1 alters the 3'-UTR of mRNA to promote lung fibrosis
• Comprehensive characterization of circular RNAs in ~ 1000 human cancer cell lines
• Interferon regulatory factor 7 (IRF7) represents a link between inflammation and fibrosis in the pathogenesis of systemic sclerosis
• Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema
• 校正：microRNA-101通过抑制成纤维细胞增殖和激活来减轻肺纤维化
• Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation
• Coordination of ENT2-dependent adenosine transport and signaling dampens mucosal inflammation
• Elevated ecto-5'-nucleotidase: a missing pathogenic factor and new therapeutic target for sickle cell disease
• 短期缺氧通过增强的腺苷释放和腺苷2B受体刺激抑制体内炎症
• 裂解因子IM 25的抑制可通过替代聚腺苷酸化促进肺癌细胞的增殖
• Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension
• A的抗纤维化作用_2BAdenosine Receptor Antagonism in a Mouse Model of Dermal Fibrosis

Education & Training

PhD, Thomas Jefferson University, 1993

Research Info

Adenosine signaling and the regulation of COPD and Pulmonary Fibrosis

Programs

• 生物化学和细胞生物学

News

• COVID-19 research sparks new collaboration, innovation
• GSBS Associate Dean Eric Swindell leaving in April
• New Dean
• Leston, Lewis, Yu receive 2020 President’s Awards for Leadership
• 2019 President’s Scholar Awards: Four scholars receive UTHealth’s most distinguished award
• First Houston post-coronavirus clinic part of new UTHealth COVID-19 Center of Excellence
• 博士生布莱克本（Blackburn
• Two studies reveal pregnant women bear greater risk of hemorrhagic stroke