Jun Wang
助理教授
休斯敦德克萨斯大学健康科学中心
麦戈文医学院
儿科系
王的实验室研究,旨beplay苹果手机能用吗在了解信号ing pathways such as Hippo, Wnt and Bmp pathways as well as non-coding RNAs in regulating craniofacial and heart development, diseases and regeneration. For example, one of the cardiac projects is to investigate the function and molecular regulatory mechanism of the cardiac conduction system (CCS) homeostasis and regeneration. Dysfunction of CCS leads to cardiac arrhythmia, a major cause of death worldwide. With the long term goal of developing novel methods to treat CCS dysfunction, we have obtained promising preliminary data suggesting an important role of Hippo signaling, a critical an organ size controller, in CCS homeostasis, and Hippo repression protects the CCS from damage. One of the craniofacial projects is to study the cross talk between Hippo and Wnt pathways in regulating the development of the cranial neural crest cells, the migrating multipotent cells giving rise to different derivatives composing the majority of the craniofacial structures.
正在进行的研究得到NIH赠款的支持。beplay苹果手机能用吗研究方法包括遗传小鼠模型，分子和生化技术，基因组学，蛋白质组学和下一代测序技术的组合。项目将需要使用小鼠遗传学，细胞培养和操纵，实时成像，分子生物学和生化技术，例如PCR，诱变，亚克隆，蛋白质印迹，共免疫沉淀，免疫荧光，免疫荧光等。研究也需要使用2nd生成测序技术，例如RNA-SEQ和CHIP-SEQ，以鉴定对照和疾病模型中的基因变化，以及CRISPR-CAS9基因组编辑技术，以生成特定的基因敲除细胞系和小鼠模型。
教育与培训
博士- 德克萨斯A＆M健康科学中心 - 2010年