R. Eric Davis
Associate Professor
The University of Texas MD Anderson Cancer Center
Department of Lymphoma and Myeloma
我的目标是通过继续对细胞信号传导的重点工作并建立主动转化基因组学计划来改进淋巴瘤和骨髓瘤的治疗。我目前的信号感兴趣是理解某些类型的淋巴瘤中B细胞受体信号的机制，从而导致NF-kappab和其他途径的组成型激活，并识别可以抑制这种小分子的小分子。我的基因组学实验室目前专注于使用基因表达分析来了解淋巴瘤和骨髓瘤部门的许多临床试验中的一些疗法反应，以便能够提供其他基因组分析，例如Array CGH。尽管存在重叠的机会，但我的实验室中的教程将重点放在使用细胞系或使用患者样品的翻译基因组学上的细胞信号研究。
Projects/Techniques:
Work on cell signaling primarily involves the creation and use of engineered cell lines for functional studies. Techniques include reporter assays, molecular cloning, use of viral vectors, flow cytometry, sequencing, RNA interference, gene expression analysis, and homologous recombination. Work on translational genomics primarily involves microarray measurement of mRNA levels for gene expression profiling of tumor samples and other patient materials. Other techniques or molecules may be utilized, e.g. qRT-PCR, SNP arrays, or genomic sequencing. Results will be analyzed primarily for correlation with response to specific treatment, to identify gene signatures that may be used for prediction, therapy assignment, or identifying pathways that determine outcome. This will involve bioinformatic and biostatistical approaches such as gene set enrichment analysis.
教育和培训
M.D. - Medical University of South Carolina - 1984