Bisrat Debeb
Assistant Professor
The University of Texas MD Anderson Cancer Center
Department of Breast Medical Oncology
beplay苹果手机能用吗我的实验室的研究重点是研究乳腺癌侵袭性，转移和耐药性的分子决定因素。具体而言，我们的研究工作旨在（i）识beplay苹果手机能用吗别和靶向脑转移的分子驱动因素，脑转移是晚期乳腺癌的常见和破坏性的表现。（ii）研究炎症性乳腺癌（IBC）的独特病理生物学，这是一种非常侵略性和最致命的原发性乳腺癌，对年轻和非裔美国妇女的影响不成比例。
Current efforts in the laboratory involve characterizing new drivers of brain metastasis, developing better brain metastasis mouse models and designing novel therapeutic strategies to treat or prevent brain metastasis, and characterizing novel mediators of aggressiveness and therapy resistance in IBC. Along these lines we have developed preclinical mouse models of brain metastasis from aggressive HER2+ and triple-negative breast cancer cells (JNCI, 2016) to better understand the biology and the mechanisms underlying metastatic dissemination to the brain. We also utilize cell lines, primary cell cultures, patient derived xenograft (PDX) mouse models and human tissue samples to unravel the molecular underpinnings of IBC and brain metastasis. These efforts are envisioned to provide novel therapeutic approaches with a potential to translate into the clinic for improved breast cancer patient survival.
A tutorial in my laboratory would provide experience with mouse models (in vivo breast cancer studies), cell culture techniques, flow cytometry, molecular and cell biology techniques as well as cancer stem cell studies.
教育和培训
Ph.D. - Texas A&M University - 2008
D.V.M. - Addis Ababa University - 1999