Andrey Tsvetkov，博士，Uthealth Houston McGovern医学院神经病学系助理教授和研究生院教职员工均被授予Glenn医学研究基金会老年医学研究突破基金会（BIG）颁发的美国衰老研究（AFAR）。beplay苹果手机能用吗

TSVETKOV隶属于癌症生物学和神经科学领域的GSBS计划。

Big Awards为研究项目提供了300,000美元，这些项目提供了巨beplay苹果手机能用吗大的希望，即在衰老的基本生物学或基于早期发现的基础上产生转变的发现，并有可能转化为临床相关的策略，治疗方法和治疗疗法，从而使人类的衰老和健康跨度受益。获奖者是通过在衰老研究领域工作的杰出科学家的委员会通过竞争过程选择的。beplay苹果手机能用吗

“格伦医学基金会赞助的Research, in collaboration with the American Federation for Aging Research, the Breakthroughs in Gerontology initiative provides support to research projects which, if successful, offer significant promise of yielding transformative discoveries in the fundamental biology of aging,” Tsvetkov said. “I am honored that my research is recognized by this award.”

Tsvetkov received the grant for his research “G-quadruplex RNA and G-quadruplex RNA helicases in senescent astrocytes.” Senescence is a homeostatic mechanism that prevents division of old or damaged cells and cancerous transformation.

TSVETKOV说：“我们的项目将针对衰老星形胶质细胞中G-四链体-RNA相关的衰老的分子机制，其未来的目标是开发抗染色治疗干预措施。”

除了永久的细胞周期停滞外，衰老细胞还经历了许多可观察的变化，例如全球翻译，染色质重排，代谢重编程，特定的表观遗传修饰和形态变化。

衰老的一个关键特征是与衰老相关的分泌表型（SASP），涉及生长因子，细胞因子，趋化因子和金属蛋白酶酶的分泌，可介导非细胞自主衰老作用。RNA正在成为细胞衰老的关键调节剂，尽管RNA相关衰老的分子机制尚不清楚。

Tsvetkov’s collaborator on the project is医学博士Nitin Tandon, professor and chair ad interim of the Vivian L. Smith Department of Neurosurgery at McGovern Medical School and fellow GSBS faculty member. For the research, Tandon provides human astrocytes removed during surgery.

“The research supported through these 2021 grants will encourage the development of novel approaches aimed at helping us live healthier, longer,” notes K. Leonard Judson, CEO of the Glenn Foundation for Medical Research. “The Glenn Foundation for Medical Research is pleased to partner with AFAR to support early career and established investigators through these grant programs.”