Produce gram quantities of antibodies and other proteins as needed for pharmacokinetic and toxicology studies
Characterize the proteins in detail, including purity, aggregation, and post-translational modification
Remove endotoxin for in vivo studies
Generate high-expressing stable cell lines with CHO cells
Pharmacokinetic and Toxicology study in Two Species
Determine pharmacokinetic parameters of drug candidates in rats and rhesus monkeys
Determine safety and potential toxicity of drug candidates in rats and rhesus monkeys with single and/or repeat dosing
Assess safety and potential toxicity by complete blood analysis and histopathology examination of major organs
Imaging and biodistribution in tumor models
Label drug candidates with radionuclides used for positron emission tomography (PET) or single-photon emission computed tomography (SPECT)
Perform whole-body imaging at up to 7 days post-injection to determine uptake levels of the labeled drug candidates in on-target and off-target tissues
