Biography

Garsin博士是德克萨斯大学健康科学中心医学院微生物学和分子遗传学系教授。在马萨诸塞州综合医院/哈佛医学院的博士后奖学金之后，Garsin博士于2004年来到Uthealth担任助理教授。她获得了博士学位哈佛大学的生物化学及其学士学位康奈尔大学生物科学博士学位。

Garsin博士本质上是细菌遗传学家，该基础支持她对细菌发病机理，基因调节以及宿主微生物和微生物微生物相互作用的兴趣。她的研究集中于人类细菌病原体的生物学，肠球菌粪便。One NIH-funded research focus is on the roles and regulation of ethanolamine utilization inE.粪便。另一个是在模型宿主中引起的免疫反应中活性氧的生物学Caenorhabditis elegans.最后，Garsin博士研究了E.粪便和人类真菌病原体，白色念珠菌。她和她的合作者发现，微生物抑制彼此的毒力，从而鉴定出具有抗感染治疗性发育的化合物。

博士Garsin exc收到了许多称赞ellence in research and education. In 2004, she received an Ellison Medical Foundation New Scholar Award in Global Infectious Disease. In 2008, she was awarded a UT Young Investigator award. She was the recipient of the Dean’s Teaching Excellence Award in multiple years. Finally, Dr. Garsin was elected as a Fellow to the American Academy for Microbiology in 2019. She has served on many review panels including a term as a permanent member of the Prokaryotic Cell and Molecular Biology (PCMB) NIH review group. Dr. Garsin is currently an associate editor of PLOS Genetics and the minireview editor for mBio.

Education

Postdoctoral Fellow
马萨诸塞州综合医院 /哈佛医学院
Ph.D.
哈佛大学，1999年

Research Information

使用先天免疫反应阐明秀丽隐杆线as a model host.
乙醇胺在细菌中的作用和调节。
Interactions betweenEnterococcus faecalisand白色念珠菌

这emergence of untreatable bacterial infection in modern medicine is due to several factors. The hospital patient population is increasingly elderly and immune-compromised, creating a pool of susceptible hosts. The overuse of antibiotics has provided the necessary selective pressure for the development of resistance. Pathogenic bacteria have seemingly endless versatility in creating and sharing mechanisms of resistance. As the development of antibiotic resistance continues to erode one of the greatest advances in modern health care, it is crucial to identify alternative strategies that can form the basis of novel anti-infective therapies. One approach is to target the immune response to more effectively dispel infection.

为此，我实验室研究的一个重点包括对宿主对病原体的反应的研究，该蠕虫使用称为病原体beplay苹果手机能用吗秀丽隐杆线as a model host.秀丽隐杆线具有良好的特征，包括短短的3天生命周期，在此期间产生了数百个后代，小规模和易于实验室种植，一个完全测序的基因组以及大量的分子和遗传工具和资源。有趣的是，秀丽隐杆线become sick and die when fed on many human pathogens, making this approach possible. Importantly, many of the same immune defense signaling pathways and mechanisms employed by higher animals appear to also be at play in the worm. For example, my laboratory discovered that秀丽隐杆线produces reactive oxygen species (ROS) in response to pathogens, a defense mechanism analogous to the oxidative burst that occurs in human phagocytic cells. We are in the process of identifying the machinery and the regulators that generate this response, characterizing its role in秀丽隐杆线免疫力，并最终运用我们的知识以更好地了解人类的这种反应。

我们对宿主对人类细菌感染的免疫反应的研究特别关注Enterococcus faecalisnow the second or third most common hospital-associated infection, but amenable to laboratory studies due to the existence of a complete array of molecular tools. In a screen for mutants attenuated in killing秀丽隐杆线我们发现，编码乙醇胺利用的操纵子中的突变影响了毒力。我们将研究重点放在剖析该操纵子的调节上，因为它包含了与转录后调节相关的几个新功能。其中包括一个adocbl结合核糖开关和一系列由RNA结合两个组分系统调节的转录终结器。现在，我们正在解剖这些特征如何共同开启和关闭乙醇胺基因的表达，并研究形成乙醇胺特异性的微校区的时空动力学，这些动力学形成了代谢。

Finally, my lab is engaged in a collaborative project with the Lorenz Laboratory studying the interactions ofE.粪便与人类真菌病原体白色念珠菌。We have recently identified a peptide secreted byE.粪便抑制了致病性和生物膜的形成白色念珠菌；它在小鼠模型中显示出治疗潜力。我们开始研究如何白色念珠菌，likewise, inhibits the virulence and biofilm formation ofE.粪便。

出版物

出版信息

Brown，A。O.D. A. Garsin（2019）。Antifungal Activity of theEnterococcus faecalis肽ENTV需要蛋白酶裂解和二硫键形成。MBIO。10，E01334-19。PMCID：6606811

Kaval, K.G., M. Gebbie, M. R. Cruz, W. C. Winkler*,D. A. Garsin*。Enterococcus faecalisUtilizes Ethanolamine in Aerobic and Anaerobic Conditions Subject to Catabolite Repression.J Bacteriol.201, e00703-18. 2019. PMCID: 6482927.

刘Y.，K。G. Kaval，A。VanHoof，D. A. Garsin（2019）。血红素过氧化物酶HPX-2保护Caenorhabditis elegansfrom Pathogens.PLOS基因。1, e1007944. PMCID: 6368334.

Graham，C。E.，M。R. Cruz，D. A. Garsin*，M。C。Lorenz*（2017）。这Enterococcus faecalisBacteriocin EntV Inhibits Hyphal Morphogenesis, Biofilm Formation, and Virulence of白色念珠菌。Proc Natl Acad Sci U S A.doi：10.1073/pnas.1620432114。PMCID：5410809。 *d。A. Garsin和M. C. Lorenz是相应的作者。

McCallum K. C.，B。Liu，J。C. Fierro-González，P。Swoboda，S。Arur，A。Miranda-Vizuete，D。A. Garsin（2016）。TRX-1在秀丽隐杆线虫中非自动调节SKN-1核定位细胞。遗传学。203，387-402。PMCID：4858787。

DebRoy, S., M. Gebbie, A. Ramesh, J. R. Goodson, M. R. Cruz, A. van Hoof, W. C. Winkler,D. A. Garsin(2014). A Riboswitch-Containing sRNA Controls Gene Expression by Sequestration of a Response Regulator.科学。345, 937-940. PMCID: 4356242.