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Dr. Mc新娘获得博士学位来自加利福尼亚大学河滨大学的指导，维克多·G·J·罗杰斯（Victor G. J. Rodgers）的指导，他的研究重点是了解拥挤的蛋白质渗透压的现象及其在医疗设备上的应用。beplay苹果手机能用吗在他的博士学位期间，他获得了许多奖学金，包括视频生物信息学的NSF IGERT奖学金和Doe Gaann奖学金。

His postdoctoral training occurred under the tutelage of Dr. John H. Zhang at Loma Linda University where he studied translational neuroscience research with an emphasis on cerebrovascular disease. During his postdoctoral work, Dr. Mc新娘获得了NHLBI的NIH F32奖，以开发和研究血管腔晕厥的动物模型。他还在工程和神经科学领域合着了几篇论文。在2017年，M博士cBride joined the Vivian L. Smith Department of Neurosurgery as an Assistant Professor.

Education

研究生学院l
Doctorate of Philosophy in Bioengineering, University of California, Riverside, CA

Areas of Interest

Research Interests

Neurological Diseases with an Emphasis on Stroke; Thermodynamics and Transport Phenomena of Crowded Protein Solutions; Bioreactions; Video Bioinformatics, Video Microscopy, and Live Imaging; Medical Imaging and Its Applications for Studying Disease and Mechanisms; Device Design with an Emphasis on Medical Devices

Research Information

The research in Dr. McBride’s lab is focused on understanding the pathophysiology of subarachnoid hemorrhage (SAH), particularly focusing on delayed cerebral ischemia (DCI). Delayed cerebral ischemia after SAH is a critical factor in the poor prognosis of surviving patients, and currently we still do not fully understand the mechanisms causing DCI. We are using live imaging to understand the cerebrovascular dynamics as they are related to ensuing injury subsequent to SAH. Additionally, we are identifying novel therapeutic targets and developing strategies aimed at attenuating DCI following SAH.

Dr. Mc新娘正在与Spiros Blackburn博士合作研究Haptoglobin表型在DCI Post-Sah中的作用。这项工作的目的是确定SAH之后患DCI和不良结果的高风险的患者。这项工作还将阐明预防DCI的新型治疗靶标。

Publications

Publication Information

Articles
1. McBride DW, Reis C, Frank E, Klebe DW, Zhang JH, Applegate II R, Tang J, “An Experimental Model of Vasovagal Syncope Induces Cerebral Hypoperfusion and Fainting-like Behavior in Awake Rats” PlosOne, accepted
2. Enkhjargal B，McBride DW，Manaenko A，Sakai Y，Tang J，Zhang JH，“维生素的鼻内给药可减轻OPN的内源性上调和激活CD44/P-GP Glycosylation subararachnoid smorrachnoid hemorrhage，可减轻血脑屏障的破坏在老鼠中，” JCBFM接受了
3. Lekic T, Klebe DW, Pichon P, Brandkov K, Sultan S, McBride DW, Casel D, Al-Bayati A, Ding Y, Tang J, Zhang JH, “Aligning Animal Models of Clinical Germinal Matrix Hemorrhage, from Basic Correlation to Therapeutic Approach,” Curr Drug Targets, in print (2016)
4. McBride DW, Tang J, Zhang JH, “Maintaining Plasma Fibrinogen Levels and Fibrinogen Replacement Therapies for Treatment of Intracranial Hemorrhage,” Curr Drug Targets, in print (2015)
5. Klebe D, Flores JJ, McBride DW, Zhang JH, Tang J, “Modulating the Immune Response Towards a Neural Regenerative Phenotype after Cerebral Hemorrhage,” J Neuroimmune Pharmacol, 10(4):576-86 (2015), DOI: 10.1007/s11481-015-9613-1
6. McBride DW, Wang Y, Adam L, Oudin G, Walker C, Louis J-S, Tang J, Zhang JH, “Correlation Between Subacute Sensorimotor Deficits and Brain Edema in Rats after Surgical Brain Injury,” Acta Neurochir Suppl, Proceed International Symposium Brain Edema XVI, 121:317-21 (2016), DOI: 10.1007/978-3-319-18497-5_55
7. McBride DW, Donovan V, Hsu M, Obenaus A, Rodgers VGJ, Binder DK, “Reduction of Cerebral Edema via an Osmotic Transport Device Improves Functional Outcome after Traumatic Brain Injury in Mice,” Acta Neurochir Suppl, Proceed International Symposium Brain Edema XVI, 121:285-9 (2016), DOI: 10.1007/978-3-319-18497-5_49
8. McBride DW, Matei N, Câmara JR, Louis J-S, Oudin G, Walker C, Adam L, Liang X, Hu Q, Tang J, Zhang JH, “Acute Hyperglycemia does not Effect Brain Swelling or Infarction Volume after Middle Cerebral Artery Occlusion in Rats,” Acta Neurochir Suppl, Proceed International Symposium Brain Edema XVI, 121:251-5 (2016), DOI: 10.1007/978-3-319-18497-5_44
9. McBride DW, Legrand J, Krafft PR, Tang J, Zhang JH, “Acute Hyperglycemia is Associated with Immediate Brain Swelling and Hemorrhagic Transformation after Middle Cerebral Artery Occlusion in Rats,” Acta Neurochir Suppl, Proceed International Symposium Brain Edema XVI, 121:237-41 (2016), DOI: 10.1007/978-3-319-18497-5_42
10. McBride DW, Jacob C, Doycheva D, Dixon BJ, Malaguit J, Lekic T, Tang J, Zhang JH, “Changes in Brain Swelling and Infarction Volume over Four Days after Hypoxia Ischemia in Neonatal Rats,” Acta Neurochir Suppl, Proceed International Symposium Brain Edema XVI, 121:111-4 (2016), DOI: 10.1007/978-3-319-18497-5_19
11.麦克布莱德DW,唐J,张JH,”发展an Infarct Algorithm to Correct for Brain Swelling After Ischemic Stroke in Rats,” Acta Neurochir Suppl, Proceed International Symposium Brain Edema XVI, 121:103-9 (2016), DOI: 10.1007/978-3-319-18497-5_18
12. Lekic T, Hardy M, Fujii M, McBride DW, Zhang JH, “Brain Volume Determination in Subarachnoid Hemorrhage Using Rats,” Acta Neurochir Suppl, Proceed International Symposium Brain Edema XVI, 121:99-102 (2016), DOI: 10.1007/978-3-319-18497-5_17
13. McBride DW，Wang Y，Sherchan P，Tang J，Zhang JH，“大鼠外科手术脑损伤后亚急性感觉运动缺陷与脑含量之间的相关性”，Beact Brain Res，290：161-71（2015），DOI：DOI：DOI：：10.1016/j.bbr.2015.05.001
14. McBride DW, Klebe D, Tang J, Zhang JH, “Correcting for Brain Swelling’s Effects on Infarct Volume Calculation After Middle Cerebral Artery Occlusion in Rats,” Trans Stroke Res, 6(4):323-38 (2015), DOI: 10.1007/s12975-015-0400-3
15. Lekic T, Klebe D, McBride DW, Manaenko A, Flores JJ, Altay O, Rolland WB, Tang J, Zhang JH, “Protease-Activated Receptor 1 and 4 Signaling Inhibition Reduces Preterm Neonatal Hemorrhagic Brain Injury,” Stroke, 46(6):1710-3 (2015), DOI:10.1161/STROKEAHA.114.007889
16. Li L, McBride DW, Doycheva D, Dixon BJ, Krafft PR, Tang J, Zhou C, Zhang JH, “G-CSF Attenuates Neuroinflammation and Stabilizes the Blood-Brain Barrier via the PI3K/Akt/GSK-3 Signaling Pathway Following Neonatal Hypoxia-Ischemia in Rats,” Exp Neurol, DOI:10.1016/j.expneurol.2014.12.020
17. Li L，Klebe D，Doycheva D，McBride DW，Krafft PR，Flores J，Zhou C，Zhang JH，Tang J，“ G-CSF通过新生儿低氧 - 青年毒素在大鼠中，通过GSK-3抑制来缓解神经元凋亡，”Exp Neurol，263：141-9（2015），10.1016/j.expneurol.2014.10.004
18. Liang X, Hu Q, Li B, McBride D, Bian H, Spagnoli P, Chen D, Tang J, Zhang JH, “Follistatin-Like 1 Attenuates Apoptosis via Disco-Interacting Protein 2 Homolog A/Akt Pathway After Middle Cerebral Artery Occlusion in Rats,” Stroke, 45:3048-54, (2014), DOI: STROKEAHA.114.006092
19. McBride DW，Szu JI，Hale C，Hsu MS，Rodgers VGJ，Binder DK，“使用渗透传输设备进行严重TBI后，减少大脑水肿”，J Neurotrauma，31（23）（23）：1948-54，（2014年），（2014年，（2014年）），doi：10.1089/neu.2014.3439
20. McBride DW, Rodgers VGJ, “A Generalized Free-Solvent Model for the Osmotic Pressure of Multi-Component Solutions Containing Protein-Protein Interactions,” Math Biosci, 258:72-87 (2014), DOI: 10.1016/j.mbs.2014.04.002
21. Hong Y, Shao A, Wang J, Chen S, Wu H, McBride DW, Wu Q, Sun X, Zhang J, “Neuroprotective Effect of Hydrogen-Rich Saline Against Neurologic Damage ad Apoptosis in Early Brain Injury Following Subarachnoid Hemorrhage: Possible Role of the Akt/GSK3 Signaling Pathway,” PLOS One, 9(4):e96212 (2014), DOI: 10.1371/journal.pone.0096212
22. Krafft PR, McBride DW, Lekic T, Rolland WB, Mansell CE, Ma Q, Tang J, Zhang JH, “Correlation Between Subacute Sensorimotor Deficits and Brain Edema in Two Mouse Models of Intracerebral Hemorrhage,” Behav Brain Res, 264:151-60 (2014), DOI: 10.1016/j.bbr.2014.01.052
23. McBride DW, Rodgers VGJ, “Predicting the Activity Coefficients of Free-Solvent for Concentrated Globular Protein Solutions Using Independently Determined Physical Parameters,” PLoS One, 8(12):e81933 (2013), DOI: 10.1371/journal.pone.0081933
24. McBride DW, Rodgers VGJ, “Interpretation of Negative Second Virial Coefficients from Non-Attractive Protein Solution Osmotic Pressure Data: An Alternative Perspective,” Biophys Chem, 184:79-86 (2013), DOI: 10.1016/j.bpc.2013.09.005
25. Ornelas D，Ozaki NU，McBride DW，Rodgers VGJ，“牛血清白蛋白的渗透压在氯化钙具有低离子强度的情况下”，加利福尼亚大学本科研究杂志，VII：62（2013）（2013年）beplay苹果手机能用吗
26. McBride DW, Hsu MS, Rodgers VGJ, Binder DK, “Improved Survival Following Cerebral Edema Using a Novel Hollow Fiber-Hydrogel Device,” J Neurosurgery, 116(6):1389-94 (2012), DOI: 10.3171/2012.2.JNS111540
27. McBride DW, Rodgers VGJ, “Obtaining Protein Solvent Accessible Surface Area (SASA) when Structural Data is Unavailable Using Osmotic Pressure,” AIChE J, 58(4):1012-7 (2012), DOI: 10.1002/aic.12648

Book Chapters
1. Esfahani ET，McBride DW，Shafiei SB，Obenaus A，“使用基于对称的算法对T2加权磁共振图像的创伤性脑损伤的实时分析”，《视频bioinformatics》一章，Springer，Springer，接受，接受
2. McBride DW，Nowrangi D，Ho WM，Tang J，Zhang JH，“在大鼠中急性高血糖症状后，诱导大脑中部动脉闭塞后的出血转化”，《急性神经伤害》的动物模型，《人类审查》，《审查》，正在研究
3. McBride DW, Lekic T, Tang J, Zhang JH, “A Rat Model of Cerebellar Hemorrhage using Bacterial Collagenase Injection,” Book Chapter in Animal Models of Acute Neurological Injuries, Humana Press, under review
4. Sherchan P，McBride DW，Akyol O，Huang L，Reis C，Kim C，Tang J，Zhang JH，“手术脑损伤的大鼠模型”，《急性神经损伤动物模型》的书籍章节，《人类出版社》，《人类出版社》，下审查
5. Ho WM, Reis C, Akyol O, Cahill J, McBride D, Zhang JH, “Monofilament Perforation Subarachnoid Hemorrhage Rat Model,” Book Chapter in Animal Models of Acute Neurological Injuries, Humana Press, under review
6. Iniaghe LO, McBride DW, Lekic T, Tang J, Zhang JH, “Collagenase Induced Pontine Hemorrhage in Rats,” Book Chapter in Animal Models of Acute Neurological Injuries, Humana Press, under review