2. Innovation and Quality Program

Innovation and Quality Program

OVERVIEW

A major part of our mission involves innovation, both to deliver the highest quality care today, and to define new treatments for the future. Our Innovation and Quality (IQ) Program serves to facilitate these goals. Directed byDong Kim和Gigi Hergenroeder, the IQ program includes principal investigators, biostatisticians, research nurses, coordinators, data managers, programmers, research assistants, and hospital and clinic administrations.

智商程序有两个组件。首先，它直接与临床医生合作，使用数据和详细的反馈来帮助医生提高其表现并带来更好的患者结局。其次，智商计划提供了一个平台和支持，以有效地进行广泛的研究研究。具体而言，智商计划的目的是：

  • 组织数据以改善医师和服务绩效
  • 培养衡量质量和跟踪长期患者预后的创新方法
  • Enhance infrastructural support to enable faculty to conduct a range of clinical trials and patient-centered research

该计划认识到，提高医疗保健质量的关键是给提供者及时详细的有关其绩效的反馈。这样的常规报告不仅使医生更加了解自己的个人质量基准，而且还使他们能够确定可以改善的特定领域。而且，由于这些反馈的形式是医生本身已经定义和验证的指标和数据的形式，因此提供者更有可能接受这些变更计划。

为了简化这些报告的汇编和交付，智商计划旨在为神经外科疾病创建数据集，以监控医师的整体绩效和患者结果。例如，通过添加国立神经系统疾病研究所和中风推荐的特定措施来评估创伤性脑损伤（TBI）的治疗反应（TBI）。通过以指定的间隔纳入这些标准化的神经系统结果措施，可以将患者的进展与基线以及其神经系统疾病的组规范进行比较。

但是，质量结果不仅可以通过衡量医生的表现来确定。智商计划认识到患者的结果和满意度是全面评估护理的关键组成部分。过去，医生和护士定期跟踪标准质量指标。现在，他们专门研究了与医疗提供者不同干预措施不同的积极和负面的患者结果。为此，智商计划将多个结果指标纳入每个患者的常规临床访问中。利用这些结果工具，我们可以长期测量恢复方面，例如认知和神经系统地位，疼痛和残疾水平，生活质量以及患者如何看待我们的干预结果。长期结局的跟踪将产生我们表现以及治疗功效的更准确，更详细的情况。

Included in the IQ program is the Neuroscience Research Repository, a large bio-bank housing patient samples for research. During admission to our hospital patients are invited to participate in the Neuroscience Research Repository (NRR). With an affirmative response, de-identified clinical data coupled with residual tissue samples (blood, cerebrospinal fluid, tumors) are collected for research purposes. By using the NRR to collect DNA samples and obtain detailed family histories on intracranial aneurysm patients, Dr. Dong Kim and Dr. Teresa Santiago-Sim, for example, were able to identify a gene mutation present in a subset of patients who develop intracranial aneurysms. Furthermore, Gigi Hergenroeder, Pramod Dash, Ph.D., Alex Choi, M.D. and Jay Zhu, M.D. use NRR to obtain blood and cerebrospinal fluid to look for biomarkers in spinal cord injury, traumatic brain injury, subarachnoid hemorrhage and brain tumors. Biomarkers may facilitate the evaluation of responses to treatment and the determination of patient-specific treatments, that is to say, more personalized medicine. From a research perspective, biomarkers can also be used as early surrogate measures of outcomes, thus decreasing the time and cost of clinical trials.

临床试验的促进是智商计划的另一个重点。除统计和监管支持外，智商团队还包括护士，物理治疗师，遗传辅导员，研究协调员和助手，以筛查，同意和招募患者以及处理样本。beplay苹果手机能用吗正在进行的审判的一个例子是需要撤离硬膜下血肿的患者的体温过低：一项多中心，随机临床试验，“希望试验”. The primary objective of this study is to test whether hypothermia improves patient outcomes following a traumatic brain injury with subdural hematoma. We are the lead center in this trial and we expect it to provide definitive evidence regarding the utility of early hypothermia in the treatment of subdural hematoma. We also have a large number of active clinical studies to foster innovation. A sample of current trials is listed below.

The result of these efforts is an active quality program that has placed us among the best programs in the country.

积极研究

  • Reconstruction of glioblastoma multiforme (GBM) using iPSC and CRISPR technologies.PI:刘英,博士。
  • 通过生物标志物识别胶质母细胞瘤亚型的新工具的验证。PI:Jay Zhu, M.D.
  • 研究用替莫唑胺和贝伐单抗治疗的死后胶质母细胞瘤标本中的分子异常，以及与MRI变化的相关性。PI:Jay Zhu, M.D.
  • 对组织损伤和临床结局的近日围栏反应（Portico）。PI:Spiros Blackburn，医学博士
  • Coagulation and Outcome from Acute Neurologic Injury Using Thrombelastography.PI:蒂法尼·张（Tiffany Chang），医学博士
  • TBI中生物标志物发现的样本分析。PI:Pramod Dash博士
  • A Mechanism for Global Cerebral Edema after Subarachnoid Hemorrhage: Pathophysiology of early brain injury.PI:H. Alex Choi, M.D.
  • Genetic Basis of Cerebral Aneurysms.PI:Dong H. Kim, M.D.
  • The creation of vector-free human iPS cells from fibroblasts from acute and chronic SCI patients by direct delivery of reprogramming proteins.PI:Qi Lin Cao, Ph.D.
  • Phase I/II Dose-Escalation Study of TPI 287 in Combination with Bevacizumab Followed by Randomized Study of the Maximum Tolerated Dose of TPI 287 in Combination with Bevacizumab versus Bevacizumab Alone in Adults with Recurrent Glioblastoma.PI:Sigmund Hsu, M.D.
  • 动脉内血管痉挛试验：一项多中心随机研究。PI:彭罗克·陈（Peng Roc Chen）
  • Methotrexate Infusion Directly into the Fourth Ventricle in Children with Malignant Fourth Ventricular Brain Tumors: A Pilot Clinical Trial.PI:David I. Sandberg，医学博士
  • The National Center for Testing Treatments in Chronic Spinal Cord and Traumatic Brain Injury (NCTT). PI Dong Kim, MD
  • 群集头痛和三叉神经痛（WEC）的Will Erwbeplay苹果手机能用吗in头痛研究中心研究。PI：马克·伯里什（Mark Burish），医学博士
  • Subarachnoid Hemorrhage Recovery and Galantamine (SAHRANG). PI: H. Alex Choi, MD
  • Restoring Hand Function Utilizing Nerve Transfers in Persons with Cervical Spinal Cord Injuries. PI: Daniel Kim, MD and Dong Kim, MD

IQ PROGRAM PERSONNEL

Medical Director
医学博士邓金（Dong Kim）

Director
Georgene Hergenroeder，M.H.A，R.N。

战略分析总监
Miriam Morales

医师研究人员beplay苹果手机能用吗
医学博士Spiros Blackburn
马克·伯里什（Mark Burish），医学博士
蒂法尼·张（Tiffany Chang），医学博士
亚历克斯·崔（Alex Choi）
Joseph Hsieh, M.D.
Sigmund Hsu, M.D.
Daniel H. Kim, M.D.
Ryan Kitagawa，医学博士
Kiwon Lee，医学博士
卡尔·施密特博士
Jay Zhu, M.D.

Clinical Researchers
丽塔·科尔（Rita Cole），PT，DPT，NCS，物理治疗师
Krista Qualmann, MS, CGC, Genetic Counselor
Lisa Schmitt, BSN, RN, Nurse Manager
Elena Viverette，MS RN，高级研究护士beplay苹果手机能用吗

质量和分析
拉尔夫·萨拉萨（Ralph Salazar），女士
Alex Liu, MS
乔安娜·奥利里（Joanna O’Leary）博士
Rahil Tai, M.D.

Research Coordinators/Assistants
Mollie Ahn，MBA
约书亚·卡哈尔（Joshua Cahal），女士
Elena Espino, BS
Melissa Franch，BS
Christopher Hawkins, MS
格雷格·卢（Greg Lu），医学博士
Kanako Matsumura, BA
Mayank Rao
Aditya Sanzgiri
Davis So, BS
Ebony Spivey
托马斯·沙利文（Thomas Sullivan），BS
Dora Torres, BS
Glenda Torres，MS