2. Laboratory of Devin McBride, Ph.D.

Laboratory of Devin McBride, Ph.D.

OVERVIEW

Research in the Mc新娘脑血管实验室的重点是理解导致蛛网膜下腔出血（SAH）（SAH）后神经缺陷延迟的机制，并鉴定出新的治疗靶标。我们目前的工作围绕着脑血管收缩和微栓性，这被认为是SAH后神经系统缺陷延迟的主要因素。我们正在使用SAH的动物模型以及细胞培养物来阐明延迟缺陷的病理生理机制，并确定潜在的治疗靶标，以防止这种功能损伤。我们还与Spiros Blackburn合作，以确定SAH后的凝血和血小板功能的变化，作为延迟神经缺陷和患者预后不佳的潜在生物标志物。

Dr. Devin McBride is an Assistant Professor in the Department of Neurosurgery at the University of Texas Health Science Center at Houston. He obtained his Ph.D. in Bioengineering from the University of California, Riverside and trained as a postdoctoral fellow in John H. Zhang’s lab at Loma Linda University where he learned translational neuroscience focused on cerebrovascular diseases. Our laboratory is currently supported by a Brain Aneurysm Foundation grant.

AboutDevin McBride, Ph.D.

当前的项目

  • 研究SAH后血小板在微骨形成中的作用
  • 确定甘氨酸在SAH后预防炎症的治疗潜力
  • Evaluate the haptoglobin-CD163 axis for hemoglobin clearance after SAH

TEAM MEMBERS

Remya Veettil, Ph.D., Postdoc

CONTACT

电子邮件：devin.w.mcbride@uth.tmc.edu

Office Phone: 713-500-6169

SELECTED PUBLICATIONS

  1. Kumar PT，McBride DW, Dash P, Matsumura K, Rubi A, Blackburn SL, “Endothelial Cell Dysfunction and Injury in Subarachnoid Hemorrhage,”Mol Neurobiol，doi：10.1007/s12035-018-1213-7
  2. Blackburn S, Kumar PT,McBride D，Zeineddine HA，Leclerc J，Choi A，Dash P，Grotta J，Aronowski J，DoréS，“动脉瘤性蛛网膜下腔出血中的抗果胶和Haptoglobin基因型的独特贡献，”Front Physiol,9: 592 (2018):10.3389/fphys.2018.00592
  3. Gong L，Manaenko A，Fan R，Huang L，Enkhjargal B，McBride DW，Ding Y，Tang J，Xiao X，Zhang JH，“骨桥蛋白在脑出血后通过JAK2/STAT1途径通过JAK2/STAT1途径减轻炎症，”Neuropharm,138：160-169（2018），doi：10.1016/j.neuropharm.2018.06.009
  4. Ho W-M，Akyol O，Reis H，Reis C，McBride DW, Thome C, Zhang JH, “Autophagy after Subarachnoid Hemorrhage: Can Cell Death be Good?”Curr Neuropharm, DOI: 10.2174/1570159X15666171123200646
  5. Zhang Y, Ding Y, Lu T, Zhang Y, Xu N,McBride DW, Tang J, Zhang JH, “Biliverdin Reductase-A Attenuated GMH-Induced Inflammatory Response in the Spleen by Inhibiting Toll-Like Receptor-4 through eNOS/NO Pathway,”J Neuroinflammation,15：118（2018），doi：10.1186/s12974-018-1155-Z
  6. Zhang Y, Ding Y, Lu T, Zhang Y, Xu N, Yu L,McBride DW, Flores JJ, Tang J, Zhang JH, “Biliverdin Reductase-A Improves Neurological Function in a Germinal Matrix Hemorrhage Rat Model,”Neurobiol Dis,110:122-132 (2018), DOI: 10.1016/j.nbd.2017.11.017
  7. McBride DW, Nowrangi D, Kaur H, Wu G, Huang L, Lekic T, Tang J, Zhang JH, “A Composite Neurobehavioral Test to Evaluate Acute Functional Deficits after Cerebellar Hemorrhage in Rats,”J Cereb Blood Flow Metab,38(3):433-446 (2018), DOI: 10.1177/0271678X17696509
  8. McBride DW, Blackburn S, Kumar T P, Matsumura K, Zhang JH, “The Role of Thromboinflammation in Delayed Cerebral Ischemia after Subarachnoid Hemorrhage,”前神经,8:555 (2017), DOI: 10.3389/fneur.2017.00555
  9. Krafft PR,McBride DW, Rolland WB, Lekic T, Flores JJ, Tang J, Zhang JH, “a7 Nicotinic Acetylcholine Receptor Stimulation Attenuates Neuroinflammation through JAK2-STAT3 Activation in Murine Models of Intracerebral Hemorrhage,”Biomed res int,2017:8134653 (2017), DOI: 10.1155/2017/8134653
  10. Klebe D，Flores JJ，McBride DW, Krafft PR, Rolland WB, Lekic T, Zhang JH, “Dabigatran Ameliorates Post-Haemorrhagic Hydrocephalus Development after Germinal Matrix Haemorrhage in Neonatal Rat Pups,”J Cereb Blood Flow Metab,37（9）：3135-3149（2017），doi：10.1177/0271678x16684355
  11. Lekic T，Klebe D，Pichon P, Brankov K, Sultan S,麦克布赖德d, Casel D, Al-Bayati A, Ding Y, Tang J, Zhang JH, “Aligning Animal Models of Clinical Germinal Matrix Hemorrhage, From Basic Correlation to Therapeutic Approach,”Curr Drug Targets,18(12):1316-1328 (2017), DOI: 10.2174/1389450117666160615100538
  12. McBride DW, Tang J, Zhang JH, “Maintaining Plasma Fibrinogen Levels and Fibrinogen Replacement Therapies for Treatment of Intracranial Hemorrhage,”Curr Drug Targets,18(12):1349-1357 (2017), DOI: 10.2174/1389450117666151209123857
  13. Enkhjargal B,McBride DW，Manaenko A，Sakai Y，Tang J，Zhang JH，“维生素的鼻内给药可通过OPN的内源性上调和CD44/P-GP糖基化信号的激活来减轻血脑屏障的破坏，从而减轻大鼠下血后的CD44/P-GP糖基化信号。”J Cereb Blood Flow Metab,37（7）：2555-66（2016），doi：10.1177/0271678x16671147
  14. Klebe D，Flores JJ，McBride DW, Zhang JH, Tang J, “Modulating the Immune Response Towards a Neuroregenerative Peri-Injury Milieu after Cerebral Hemorrhage,”J Neuroimmune Pharmacol,10(4):576-86 (2015), DOI: 10.1007/s11481-015-9613-1
  15. Lekic T，Klebe D，McBride DW, Manaenko A, Flores JJ, Altay O, Rolland WB, Tang J, Zhang JH, “Protease-Activated Receptor 1 and 4 Signaling Inhibition Reduces Preterm Neonatal Hemorrhagic Brain Injury,”Stroke,46(6):1710-3 (2015), DOI:10.1161/STROKEAHA.114.007889