$3 million grant awarded to determine genetic relationships to heart failure in minorities
A $3 million grant to determine how genes affect a person’s risk for heart failure has been awarded to Bing Yu, PhD, The JLH Foundation Chair in Transplant Prevention at UTHealth Houston School of Public Health.
该项目与马里兰州的Vasan Ramachandran共同领导，这是德克萨斯大学公共卫生学院圣安东尼奥大学的就职院长，该学院是圣安东尼奥UT健康和得克萨斯大学圣安东尼奥分校的合作伙伴。
国家心脏，肺部和血液研究所（NHLBI）提供的资金将是美国国立卫生研究院的一部分，将促进研究扩大心脏病研究参与者的研究，包括主要是黑人和西班牙裔人群。beplay苹果手机能用吗
Heart disease remains the leading cause of death in men and women in the U.S., and more than 6.5 million Americans experience the chronic and progressive condition. Statistics have shown that those of Black or African American descent have a higher likelihood of heart failure.
Heart failure, an umbrella term referring to several common heart conditions, is associated with a 50% mortality rate within five years. The condition is often an outcome of other health risk factors such as hypertension, diabetes, organ failure, and obesity. While these risk factors are proven contributors to heart failure, Yu’s research will identify the genetic architecture of heart failure patients to see which genes may have contributed to their condition(s).
研究人员beplay苹果手机能用吗希望识别导致心力衰竭的基因，以便采取预防措施。
“总是最好的预防而不是治疗。通过基因筛查，我们可以看到某人是否有心力衰竭的风险，并且更努力地监测，连续筛查和预防干预措施。” Yu说。
虽然先前的研究表明，遗传组成有beplay苹果手机能用吗助于导致心力衰竭的疾病，但Yu说，很少存在表征遗传关联的数据，例如心脏结构和功能的稀有和结构变异，尤其是在少数群体中。
YU计划扩大国家数据集，包括更多的非白人参与者。
“Our study leverages whole genome sequencing data from the Trans-Omics for Precision Medicine (TOPMed) program, an initiative sponsored by NHLBI, providing an unprecedented opportunity to comprehensively assess genetic susceptibility of heart failure, specifically in understudied populations,” said Yu, associate professor in the Department of Epidemiology, Human Genetics, and Environmental Sciences at UTHealth School of Public Health.
通过审查从健康结果中收集的数据，以及来自超声心动图的定量评估，YU和她的其他七个机构的研究人员团队可以确定基因是否对结果和心脏成像测量有任何影响。beplay苹果手机能用吗
她说：“关于DNA如何影响某人患末期心beplay苹果手机能用吗脏病的风险的研究差距存在差距。”
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