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检测COVID-19感染波的方法可以在大流行期间塑造关键的公共卫生决策

Photo of Marcia Otto, PhD, MS, of UTHealth Houston, who led research about establishing a model for predicting future waves in a pandemic. Photo by UTHealth Houston
Uthealth Houston的MARCIA OTTO博士主持了有关建立一个模型来预测大流beplay苹果手机能用吗行中未来波浪的模型的研究。(图片由休斯顿uthealth摄)

根据来自当地卫生部门的案例调查数据和当地机构的住院记录的方法,可以在大流行期间客观检测新的感染浪潮。beplay苹果手机能用吗UthealthHouston

Results of the findings were published inScientific Reports

“在大流行中,大多数试图预测新波的预测模型失败了。这部分是由于知识有限或有关影响社区传播的主要因素的数据。此外,影响感染传播的条件正在迅速发生变化 - 面具使用要求,限制移动性,学校和商业关闭的措施。”玛西娅·奥托(Marcia Otto),,,,PhD, MS, lead author and associate professor of epidemiology at UTHealth School of Public Health. “Messy, ‘real-world’ data can be difficult to use. We needed a method that could reliably detect new outbreak waves and determine the critical time period before local hospitals might become overwhelmed.”

To conduct their study, the researchers used two sets of data: case investigation data from the Harris County Public Health Department, and molecular test results from patients admitted to Texas Medical Center institutions.

They adapted a previouslypublished使用隐藏的马尔可夫模型识别爆发波中的四个阶段的框架:滞后,指数/快速生长,减速和固定/线性。这项先前的工作已用于描述各个国家的爆发浪潮,但并未用于量化当地社区的传播或严重疾病的动态,这对于有助于为有需要的人提供保护和照顾的公共卫生策略至关重要测试或医院护理。

奥托说:“空前的合作使这项工作成为可能,包括公共卫生科学,实践和公共卫生领导。”“这种合作对于照顾当地社区至关重要。”

哈里斯县发现了两次大浪。从2020年5月12日至9月20日的第一波浪潮花了12天的时间从当地社区到医院环境。第二个,从2020年9月27日到2021年5月15日,花了更长的时间在36天。这项工作是与哈里斯县公共卫生和哈里斯健康合作进行的。

奥托说:“目前,作为这项工作的一部分开发的方法正在用于监测哈里斯和布本德县的社区传播动态,可用于跟踪未来广泛传播性的传染病。”

Co-authors from UTHealth Houston were Frances Brito, MS; Ji Yun Tark, MPH; Jose-Miguel Yamal, PhD; Dritana Marko, MD, MSc; Shreela Sharma, PhD, RD; Michael R. Brown; Savitri N. Appana; Alison M. Rector; Steven H. Linder, PhD; Alanna Morrison, PhD; and Eric Boerwinkle, PhD, dean, professor, and M. David Low Chair in Public Health and Kozmetsky Family Chair in Human Genetics. Boerwinkle, Yamal, and Morrison are members of The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences

Co-authors also included Eric Bakota, MS; and Jennifer Kiger, MPH, with Harris County Public Health Department; and Karen C. Tseng, with Harris Health System.

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