Uthealth Houston研beplay苹果手机能用吗究人员授予超过600万美元的CPRIT赠款

德克萨斯州的癌症预防与研究所（CPRIT）向休斯顿Ubeplay苹果手机能用吗thealth Houston的研究人员授予了超过600万美元，以帮助进行癌症预防研究。这些奖项将使预防肝癌的预防措施扩大到无家可归的人，促进有关HPV疫苗的交流，并找到可以帮助破坏胃肠道癌细胞的治疗剂。

Liver Cancer Prevention Among Those with Experiences of Homelessness: An Expansion to Low-Income Housing in South Texas

A nearly $2 million grant has been awarded to Vanessa Schick, PhD, associate professor in the Department of Management, Policy and Community Health at UTHealth School of Public Health in Houston; and Jack Tsai, PhD, professor and dean of UTHealth School of Public Health in San Antonio, to lead an expansion of the program called GRASSROOTS HEALTH.

This is an innovative program in Houston and San Antonio that aims to eliminate barriers to education, testing, and treatment for hepatitis B and C among individuals at risk of homelessness. GRASSROOTS HEALTH has provided services to hundreds of individuals at risk of homelessness in Houston with existing partners at New Hope Housing and Healthcare for the Homeless Houston. This grant will allow researchers to expand the program to veterans and the South Texas region.

Tsai说：“提供乙型肝炎和C服务对于预防肝癌很重要，该社区健康项目将与具有不稳定住房历史的社区合作，将这些服务直接带入他们的家中。”

基于AI的对话代理，用于促进有关儿童和青少年HPV疫苗接种的教育和沟通

Cui Tao, PhD, professor at UTHealth Houston School of Biomedical Informatics, has been awarded $1.3 million to develop an interactive conversational agent to enhance HPV vaccine awareness. Unlike the familiar voice agents like Apple Siri or Amazon Alexa that implement a simple adjacency pairing interaction and requires user initiation, researchers will use a dialogue system that enriches a speech-enabled software agent to have prolonged, consistent, and lightweight counseling with a health consumer where the agent drives the conversation about the HPV vaccine.

“Human papillomavirus (HPV) infections cause about 34,000 cases of cancers every year in the U.S.,” Tao said. “A previous study reported that if the population were to have 70% coverage of the HPV vaccine, at least 4 million deaths worldwide could be prevented in the next decade. For the HPV vaccine to be effective, patients need to complete the two- to three-dose series. Currently, the completion rates for the HPV vaccine for adolescents in the United States population is 48.6%, short of the 80% uptake goal.”

对话系统将为代理提供有关HPV疫苗和相关主题的领域知识，以及自主对话互动的智能。beplay苹果手机能用吗研究人员将试行与父母和年轻人测试对话剂，以衡量其有效性和可行性。

Simultaneous Targeting of LGR4/5/6 for the Treatment of Gastrointestinal Cancer

beplay苹果手机能用吗休斯顿乌西顿麦戈文医学院的研究人员希望使用其100万美元的赠款来创建在杀死胃肠道癌细胞方面高度有效且有效的候选药物。

“Gastrointestinal cancers, including colorectal, stomach, and liver cancer, are major causes of cancer-related death in Texas and the rest of the U.S.,” said Qingyun Liu, PhD, principal investigator on the project and professor and director of the Center for Translational Cancer Research at The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases at McGovern Medical School. “In particular, liver cancer is becoming increasingly more common in Texas with few treatment options available. We have identified a peptibody, a protein similar to antibodies, that can specifically bind to a group of receptors on gastrointestinal cancer cells and block their function.”

beplay苹果手机能用吗研究人员希望将细胞毒性有效载荷附加到诊断剂上，该有效载荷将产生一种可以将有效载荷传递给具有高水平受体的癌细胞的肽 - 药物结合物（PDC）。“该策略与已成功用于癌症治疗的抗体 - 药物结合物（ADC）相似。该项目的成功可能会导致为广泛的癌症开发新的治疗剂。”刘说。

用靶向肿瘤的放射敏剂增强肽受体放射性核素治疗的作用

麦戈文医学院分子医学研究所副教授Ali Azhdarinia博士获得了100万美元的赠款，以开发一种新方法，以改善已FDA批准的神经内分泌肿瘤的治疗效果。

“A large proportion of these patients are already receiving an approved therapy that delivers cell-killing radiation to tumors. The effects of that treatment can be significant, but patients will eventually relapse,” said Azhdarinia.

Azhdarinia与德克萨斯大学医学博士Anderson癌症中心的联合主教研究员Daniel Halperin合作，已开发出一种新方法，使肿瘤对放射治疗更敏感，而不会损害健康的器官。

“如果成功,我们的研究将产生一个新的泰beplay苹果手机能用吗pe of tumor-targeted treatment that will be used in combination with radiation to maximize antitumor effects and reduce the likelihood of recurrence.”

头颈癌患者的淋巴功能障碍的定量NIRFLI扫描早期诊断为癌症获得性淋巴水肿

John Rasmussen, PhD, assistant professor at the Institute for Molecular Medicine at McGovern Medical School, will use a nearly $1 million grant to integrate and validate the use of computer vision technology into the near-infrared fluorescence lymphatic imaging (NIRFLI) system to scan and quantify areas of lymphatic dysfunction in patients with head and neck cancers to guide and monitor response to physiotherapy.

“Head and neck cancers are the seventh most prevalent cancer worldwide, and despite the declining use of tobacco products associated with its incidence, the prevalence of human papillomavirus (HPV) may be the reason why these cancers are rising worldwide and, in the U.S.,” said Rasmussen.

在先前的CPRIT资助下，研究人员在头颈癌患者的纵向研beplay苹果手机能用吗究中使用了NIRFLI，在数月和几年的时间内表现出持续性和进行性淋巴功能障碍。在这项新拨款中，研究人员将在当前的淋巴beplay苹果手机能用吗成像系统中添加3D成像功能，以促进临床环境中头部和颈部皮肤回流的定量。在将3D计算机视觉技术纳入系统之后，他们希望进行一项小型试验临床试验，以评估癌症治疗后12个月的淋巴处理（以及随后的淋巴水肿）对治疗的反应。

拉斯穆森说：“如果成功，我们希望提供证据表明我们的成像技术可以在临床发作前检测淋巴水肿，并且在发作前的早期治疗可能会阻止淋巴水肿的发展和/或进展。”

CPRIT grants are given to expand access to clinical trials, incubate innovative cancer research, support the state’s emerging biotechnology industry, provide needed cancer screenings for underserved Texans, and recruit outstanding cancer researchers to Texas.

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