Mission

CPM的任务是防止围手术期的器官损伤。围手术期的器官损伤是西方国家发病和死亡率的主要原因之一。如果手术后30天内的死亡被定义为疾病控制中心的独立实体，则将解释美国第三大死亡原因。在大多数情况下，手术患者的发病率归因于围手术期间的急性器官功能障碍，例如急性肾脏损伤，心肌损伤，急性肺损伤，肝损伤，肠道损伤或脓毒症。重要的是，许多基本和临床研究表明，与成功治疗完全建立的器官功能障碍的治疗相比，预防器官损伤是一个更能实现的目标。

The CPM combines different strategies to make progress toward this front. Research strategies include the following approaches:

1. Molecular studies in primary or cultured cell systems.
2. Studies of acute organ injury in mice, including acute lung and kidney injury, myocardial and hepatic injury, intestinal inflammation, and sepsis.
3. Studies in genetic mouse models. We have a library of 131 strains, with 1 background strain and 130 transgenic lines.
4. Translational studies in tissues and body fluids derived from patients with organ injury.
5. Clinical risk assessment studies.
6. Randomized, clinical trials to examine novel approaches to treat or prevent perioperative organ injury.
7. Comparative effectiveness trials to examine best clinical practice approaches to treat or prevent organ injury in surgical patients.

Some of the key elements of this program include:

1. Defining novel and exciting ways to prevent or treat acute organ injury in a wide set of diseases and patient groups (for example the heart, liver, kidney, lungs, intestine, brain, sepsis, multi-organ failure, and in diabetic patients)
2. Integration of different departments and institutions in the medical school (e.g. anesthesiology, surgery, orthopedic surgery, critical care medicine, emergency medicine, pediatrics, transplantation, hepatology, pulmonary medicine, diabetes research, and oncology). We strongly believe that research does not have departmental borders. In our experience, the integration of different view-points represented by physician scientists from different clinical departments, as well as basic scientists with different backgrounds, sets the stage for truly cutting-edge and transformative research.
3. 强调研究培训 - 尤其是beplay苹果手机能用吗医师科学家和博士学位科学家，并与GSB和MD/PHD培训计划集成。
4. Goal to help transition junior scientists to become independent researchers (e.g. K-to-R transition), and provide the platform for allowing scientists that recently achieved R01 funding to continue their success, renew their funding, and contribute to collaborative research efforts.
5. Provide the collaborative environment that would allow for successful support by the NIH of collaborative research efforts (e.g. via the PPG mechanism, or multiple PI R01 grants) and grants that support research training (e.g. via the T32 mechanism).