Hongyu Wang, MD, PhD

Education

Medical School, MD

Medicine, Southeast University, Nanjing, China, 1986

Graduate Education, MS

毒理学,Capital Medical University, Beijing, China, 1990

Graduate Education, PhD

Immunology, University of Kiel, Kiel, Germany, 1997

Postgraduate Training, Post Doc Fellowship

Hematology/Oncology, Baylor College of Medicine, 1998-2001

Research Information

**Faculty profiles will only highlight current information (the last three years). Please see the faculty’s CV for more information.

CURRENT GRANT SUPPORT:(include project title, P.I., funding agency, award period and amount)

• Society of Interventional Oncology Anil K. Pillai (PI) 07/01/2019-06/30/2021 $100,000
  Title: Identify Proteomic Biomarkers for Outcome Prediction of Lipiodol TACE Treatment
  Role: Co-Investigator
• NIH/NIDDK R21 (DK122234) Absalon D. Gutierrez (PI) 09/10/2019-06/30/2022 $582,075
  Title: GLP-1 therapy: the role of IL-6 signaling and adipose tissue remodeling in metabolic response
  Role: Co-Investigator

PAST GRANT SUPPORT:(include project title, P.I., funding agency, award period and amount)

• NIH/NCRR 5UL1TR000371 David McPherson (PI) 1/1/2006-5/31/2017
  Center for clinical and translational sciences (CCTS)
  The goal of this study is to provide infrastructure to promote translation of science into the clinic.
  Role: Director of proteomics service center
• NIH 1R21HD082947-01A1 Jerrie S Refuerzo (PI) 8/1/2015–7/31/2017
  The goal of this study is to develop nanovectors to prevent placental passage of a tocolytic agent.
  Role: Co-investigator
• Center for Clinical & Translational Sciences Core Lab Pilot Grant
  Hongyu Wang (PI) 03/1/2017-08/31/2017 $8,000
  The goal of this project is to use services of CCTS Core Laboratories for translational research projects using Morph-X-Select to discover biomarkers for triple negative breast cancer.
  Role: PI
• Center for Clinical & Translational Sciences Core Lab Pilot Grant
  H. Alex Choi (PI) 03/1/2017-08/31/2017 $8,000
  The goal of this project is to use services of CCTS Core Laboratories for translational research project “Discovery of Novel Pathways Leading to Delayed Cerebral Ischemia after Subarachnoid Hemorrhage”
  角色:Co-PI

Publications

Publication Information

**Faculty profiles will only highlight current information (the last three years). Please see the faculty’s CV for more information.

PUBLICATIONS:

Abstracts (*indicate abstracts presented at meetings)

1. Wang H., He W., Elizondo-Riojas M-A., Gorenstein D. G. New Generation CD44-X-aptamers for Targeting Human Ovarian Cancer Cells. 21th Annual Meeting of American Society of Gene and Cell Therapy, May 2018
2. Alhalawani R.H., Pillai A.K., Wang H. Understanding immune checkpoint inhibitors and the potential synergistic role of interventional radiology procedures. World Conference on Interventional Oncology (WCIO) June 2018
3. Wang H, Li X, Rao LG, Costello A, Thiviyanathan V, Li L, Volk DE. Developing Aptamers, X-aptamers and Biomarkers for Diagnosis and Targeting. NanoX Mini-Symposium, Houston, September 21, 2018
4. Patel S, Celli F, Guevara C, Bhatti Z, Pillai A, Wang H. A Panel of mRNA Molecules as Prognostic Biomarkers for Patients with Hepatocellular Carcinoma. The Society of Interventional Radiology (SIR), Austin March 23-28, 2019.
5. Wang H, Rao L.G, Volk DE, Li L, Pillai AK, Gorenstein DG. Identification of Proteomic Biomarkers Utilizing a Bead-based X-aptamer Library and Flow Cytometry Sorting. 22nd Annual Meeting of American Society of Gene and Cell Therapy. Washington D.C., April 29 – May 2, 2019.
6. Costello A, Li X, Volk DE, Pillai AK, Wang H. Selection and characterization of Vimentin-binding aptamer motifs for treatment of ovarian cancer. 22nd Annual Meeting of American Society of Gene and Cell Therapy. Washington D.C., April 29 – May 2, 2019.
7. Swaby王HK., Li X., Surabhi V., Bhatti Z., Patel M., Pillai A. Identification of mRNA-encoded prognostic biomarkers for hepatocellular carcinoma. 2020 Society of Interventional Radiology Annual Scientific Meeting. Virtual program, June 13 -14, 2020

Refereed Original Articles in Journals

1. Wang H, Lam CH, Li X, West DL, Yang X. Selection of PD1/PD-L1 X-Aptamers. Biochimie. 2017 Sep 11. pii: S0300-9084(17)30230-4. doi: 10.1016/j.biochi.2017.09.006. [Epub ahead of print]. PubMed PMID: 28912094.
2. Wang, H.; Sorolla, M.; Wang, X.; Jacobson, A.J.; Wang, H.; Pillai, A.K. Synthesis, Crystal structures and in vitro Anticancer Activity of Two New Cu(II) Coordination Compounds. Transit Met Chem (2018) 44:237-245.
3. Kuruc JC, Durant-Archibold AA, Motta J, Rao KS, Trachtenberg B, Ramos C, Wang H, Gorenstein D, Vannberg F, Jordan K. Development of anthracycline-induced dilated cardiomyopathy due to mutation on LMNA gene in a breast cancer patient: a case report. BMC Cardiovasc Disord. 2019 Jul 16;19(1):169. doi: 10.1186/s12872-019-1155-7. PMID: 31311496.
4. Wang H, Volk DE, Ganesh LR, Li L, Pillai AK, Gorenstein DG. Identification of Proteomic Biomarkers Utilizing a Bead-Based X-Aptamer Library and Flow Cytometry Sorting. Molecular Therapy 2019 27 (4), 360-360.
5. AM Costello, X Li, DE Volk, AK Pillai, H Wang. Selection and characterization of Vimentin-binding aptamer motifs for treatment of ovarian cancer. Molecular Therapy 2019 27 (4), 363-363.
6. Patel S, Pillai A, Guevara C, Celii F, Bhatti Z, Wang H. A panel of mRNA molecules as prognostic biomarkers for patients with hepatocellular carcinoma. Journal of Vascular and Interventional Radiology 2019 30 (3), S203.
7. Swaby王HK., Li X., Surabhi V., Bhatti Z., Patel M., Pillai A. Identification of mRNA-encoded prognostic biomarkers for hepatocellular carcinoma. Journal of Vascular and Interventional Radiology, Vol. 31, Issue 3, S88–S89. Published in issue: March 2020.
8. Hamidi, V., Riggs, K., Zhu, L., Bermudez Saint Andre, K., Westby, C., Coverdale, S., Dursteler, A., Wang, H., Miller Iii, C., Taegtmeyer, H., & Gutierrez, A. D. Acute Exenatide Therapy Attenuates Postprandial Vasodilation in Humans with Prediabetes: A Randomized Controlled Trial. Metab Syndr Relat Disord. 2020;18(5):225-233. doi:10.1089/met.2019.0102

Chapters

1. Lokesh, G.L., Wang, H., Lam, C.H., Thiviyanathan, V., Ward, N., Gorenstein, D.G. and Volk, D.E. in RNA Nanostructures: Methods and Protocols, Eckart Bindewald and Bruce A. Shapiro (Eds), Methods in Molecular Biology, Volume 1632, Elsevier, 2017 (in press)
   ISBN: 978-1-4939-7137-4

Other Professional Communications

Presentations (by local, regional, national, international)

1. Wang H. Morphologically-Based Tissue Aptamer Selection and Mass Spectrometry for Ovarian Cancer Biomarker Discovery. University of Texas System Proteomics Network meeting, Houston Texas, March 2017.
2. Wang H. Identification of mRNA Encoded Prognostic Biomarkers for Hepatocellular Carcinoma. Department of Diagnostic and Interventional Imaging Department Seminar, September 26,2019.
3. Wang H. Aptamer-mediated Protein Biomarker Discovery and Targeted Therapy. 1st Annual Department of Diagnostic and Interventional Imaging Research Retreat. Houston, Texas, Feb 6, 2020.
4. Wang H. Identification of New Biomarkers to Promote Personalized Treatment for Hepatocellular Carcinoma. Department of Diagnostic and Interventional Imaging Radiology Noon Conferences. Houston Texas, March 2020.

Honors and Awards

**Faculty profiles will only highlight current information (the last three years). Please see the faculty’s CV for more information.