授予研究脑膜炎的作用，败血症在阿尔茨海默氏症中
外围和脑感染在阿尔茨海默氏病发展中的作用是德克萨斯大学健康科学中心的新研究重点（beplay苹果手机能用吗UTHealth), funded with a $2 million grant from theNational Institutes of Health(NIH)。
“If we can prove the theory that infection is one of the factors that triggers Alzheimer’s disease, and specifically sepsis and meningitis, we can pay more attention to these diseases and possibly be able to avoid the onset of dementia for people in the long term,” said co-principal investigatorTatiana Barichello博士，助理教授路易斯·A·菲拉斯（Louis A. Faillace），医学博士，精神病学和行为科学系at McGovern Medical School at UTHealth.
临床前研究的主要研究者是罗德里戈·莫拉莱斯（Rodrigo Morales），博士，副教授神经病学系at McGovern Medical School at UTHealth.
Morales and Barichello will seek to identify the molecular and cellular mechanisms associated with the role of infection in the development of Alzheimer’s disease with the hope that doctors would be able to identify patients who may have an increased risk of developing the disease based on a prior diagnosis of sepsis or meningitis.
Alzheimer’s disease is a type of dementia that affects memory, thinking, and behavior. The symptoms progress and grow severe enough to interfere with daily tasks. More than 6 million Americans are living with Alzheimer’s disease, according to theAlzheimer’s Association。疾病发展的因素包括遗传学，年龄，家族史，一般生活方式和健康选择，以及疾病和健康状况，包括心脏病，中风和脑震荡。
Morales said one potential link between infections and the development of Alzheimer’s disease is the activation of the peripheral immune system. Immune response in the brain or peripheral compartments may activate resident immune cells in the brain. Although this event may be beneficial, chronic immune activation or severe acute events may lead to different clinical conditions at short or long terms.
莫拉莱斯说：“免疫系统的失衡也可能增加某些可能引发阿尔茨海默氏病的蛋白质的产生。”
的板块r link is the permeability of the blood-brain barrier. “The blood-brain barrier acts as the defense mechanism for the brain allowing certain substances to enter the brain and keeping other substances out, but during an event like an injury or infection, that barrier is compromised, which allows those substances that might be harmful to the brain to enter it. These substances can lead to the buildup of inflammation in the brain, which in turn can lead to the development of Alzheimer’s disease,” Morales said.
The study will use different approaches to analyze the potential role of infection in Alzheimer’s disease. This include the use of transgenic mice, human samples, and novel in vitro techniques. One of them is the protein misfolding cyclic amplification (PMCA) technology.
Barichello和Morales很高兴与该项目的McGovern医学院多个不同部门的一组研究人员合作。beplay苹果手机能用吗
使用的PMCA技术是由Claudio Soto, PhD，麦戈文医学院神经病学教授，乔治和辛西娅·米切尔（Cynthia Mitchell）的阿尔茨海默氏病和相关脑部疾病研究中心主任，并以前已用于研究其他几种其他疾病，包括帕金森氏病。beplay苹果手机能用吗
Other McGovern Medical School collaborators on the study from the Department of Neurology includeLouise McCullough, MD, PhD，教授兼主席以及Roy M.和Phyllis Gough Huffington神经病学系主任；Paul Schulz, MD， 教授;和Akihiko Urayama，博士, associate professor.Rodrigo Hasbun, MD, MPH, professor of infectious diseases in theDepartment of Internal Medicine也是合作者。
Morales，Barichello，Soto，McCullough，Schulz和Urayama是德克萨斯大学医学博士Anderson Cancer Center Uthealth Biomedical Sciences研究生院的教职员工。
Felipe Dal Pizzol, MD, PhD，来自巴西克里斯库玛（Criciúma）的do to to do do cartarinense也将在这项研究上进行合作。beplay苹果手机能用吗
该研究由NIH的国家老化研究所（Grant RF1AG072491）资助。